Ellagic acid is a natural phenol antioxidant found in numerous fruits and vegetables. The antiproliferative and antioxidant properties of ellagic acid have prompted research into its potential health benefits. Ellagic acid is the dilactone of hexahydroxydiphenic acid.
Plants produce ellagic acid from hydrolysis of tannins such as ellagitannin and geraniin.:208
Urolithins are microflora human metabolites of dietary ellagic acid derivatives
Ellagic acid was first discovered by chemist Henri Braconnot in 1831.:20 Maximilian Nierenstein prepared this substance from algarobilla, dividivi, oak bark, pomegranate, myrabolams, and valonea in 1905.:20 He also suggested its formation from galloyl-glycine by Penicillium in 1915. Löwe was the first person to synthesize ellagic acid by heating gallic acid with arsenic acid or silver oxide.:20 
Ellagic acid is found in oak species such as the North American white oak (Quercus alba) and European red oak (Quercus robur).
The macrophyte Myriophyllum spicatum produces ellagic acid.
Ellagic acid can be found in the medicinal mushroom Phellinus linteus.
The highest levels of ellagic acid are found in walnuts, pecans, cranberries, raspberries, strawberries, and grapes, as well as distilled beverages. It is also found in peaches and pomegranates.
Medicinal claims and research
Ellagic acid has antiproliferative and antioxidant properties in a number of in vitro and small-animal models. The antiproliferative properties of ellagic acid may be due to its ability to directly inhibit the DNA binding of certain carcinogens, including nitrosamines and polycyclic aromatic hydrocarbons. As with other polyphenol antioxidants, ellagic acid has a chemoprotective effect in cellular models by reducing oxidative stress.
Ellagic acid has been marketed as a dietary supplement with a range of claimed benefits against cancer, heart disease, and other medical problems. Ellagic acid has been identified by the U.S. Food and Drug Administration as a "fake cancer 'cure' consumers should avoid". A number of U.S.-based sellers of dietary supplements have received Warning Letters from the Food and Drug Administration for promoting ellagic acid with claims that violate the Federal Food, Drug, and Cosmetic Act.
Urolithins, such as urolithin A, are microflora human metabolites of dietary ellagic acid derivatives that are under study as anti-cancer agents. Claims that ellagic acid can treat or prevent cancer in humans have not been proven.
- ^ David S. Seigler (31 December 1998). Plant Secondary Metabolism. Springer Science & Business Media. ISBN 978-0-412-01981-4.
- ^ Larrosa, M; González-Sarrías, A; García-Conesa, MT; Tomás-Barberán, FA; Espín, JC (2006). "Urolithins, ellagic acid-derived metabolites produced by human colonic microflora, exhibit estrogenic and antiestrogenic activities". Journal of Agricultural and Food Chemistry. 54 (5): 1611–20. doi:10.1021/jf0527403. PMID 16506809.
- ^ a b c Grasser, Georg (1922). Synthetic Tannins. F. G. A. Enna. ISBN 9781406773019.
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- ^ a b D. A. Vattem; K. Shetty (2005). "Biological Function of Ellagic Acid: A Review". Journal of Food Biochemistry. 29 (3): 234–266. doi:10.1111/j.1745-4514.2005.00031.x.
- ^ Postharvest sensory and phenolic characterization of ‘Elegant Lady’ and ‘Carson’ peaches. Rodrigo Infante, Loreto Contador, Pía Rubio, Danilo Aros and Álvaro Peña-Neira, Chilean Journal of Agricultural Research, 71(3), July–September 2011, pages 445-451 (article)
- ^ Usta, C; Ozdemir, S; Schiariti, M; Puddu, PE (November 2013). "The pharmacological use of ellagic acid-rich pomegranate fruit". International journal of food sciences and nutrition. 64 (7): 907–13. doi:10.3109/09637486.2013.798268. PMID 23700985.
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- ^ 187 Fake Cancer 'Cures' Consumers Should Avoid, from the U.S. Food and Drug Administration. Accessed June 17, 2008.
- ^ Warning Letter sent to Millennium Health by the United States Food and Drug Administration, dated May 21, 2008.
- ^ Warning Letter sent to Kenton Campbell at Prime Health Direct, Ltd. by the United States Food and Drug Administration dated July 2, 2007.
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