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Edward Lawrie Tatum (December 14, 1909 – November 5, 1975) was an American geneticist. He shared half of the Nobel Prize in Physiology or Medicine in 1958 with George Beadle for showing that genes control individual steps in metabolism. The other half of that year's award went to Joshua Lederberg. Beadle and Tatum's key experiments involved exposing the bread mold Neurospora crassa
Neurospora crassa
to x-rays, causing mutations. In a series of experiments, they showed that these mutations caused changes in specific enzymes involved in metabolic pathways. These experiments, published in 1941, led them to propose a direct link between genes and enzymatic reactions, known as the "one gene, one enzyme" hypothesis. Tatum went on to study genetics in bacteria. An active area of research in his laboratory was to understand the basis of Tryptophan biosynthesis in Escherichia coli. Later, Tatum and his student Joshua Lederberg showed that E. coli could share genetic information through recombination. Tatum was born in Boulder, Colorado. He attended the college at the University of Chicago
University of Chicago
for two years,[1] and transferred to the University of Wisconsin–Madison, where he received his BA in 1931 and PhD in 1934.[2] Starting in 1937, he worked at Stanford University, where he began his collaboration with Beadle. He then moved to Yale University
Yale University
in 1945 where he mentored Lederberg. He returned to Stanford in 1948 and then joined the faculty of Rockefeller Institute in 1957. A heavy cigarette smoker, he died in New York City
New York City
of heart failure complicated by chronic emphysema. References[edit]

^ McMurray, Emily J.; Kosek, Jane Kelly; Valade, Roger M. (1995). Notable Twentieth-century Scientists: S-Z. Gale Research. p. 1970. ISBN 0810391856.  ^ " Edward Tatum
Edward Tatum
- Biographical". www.nobelprize.org. Retrieved 2018-03-03. 

Further reading[edit]

Lederberg, Joshua (1990). "Edward Lawrie Tatum 1909—1975" (PDF). Biographical Memoirs. National Academy Press. 59.  Nobel Lectures, Physiology or Medicine 1942–1962, Elsevier Publishing Company, Amsterdam, 1964

v t e

Laureates of the Nobel Prize in Physiology or Medicine

1901–1925

1901 Emil Behring 1902 Ronald Ross 1903 Niels Finsen 1904 Ivan Pavlov 1905 Robert Koch 1906 Camillo Golgi
Camillo Golgi
/ Santiago Ramón y Cajal 1907 Alphonse Laveran 1908 Élie Metchnikoff
Élie Metchnikoff
/ Paul Ehrlich 1909 Emil Kocher 1910 Albrecht Kossel 1911 Allvar Gullstrand 1912 Alexis Carrel 1913 Charles Richet 1914 Róbert Bárány 1915 1916 1917 1918 1919 Jules Bordet 1920 August Krogh 1921 1922 Archibald Hill
Archibald Hill
/ Otto Meyerhof 1923 Frederick Banting
Frederick Banting
/ John Macleod 1924 Willem Einthoven 1925

1926–1950

1926 Johannes Fibiger 1927 Julius Wagner-Jauregg 1928 Charles Nicolle 1929 Christiaan Eijkman
Christiaan Eijkman
/ Frederick Gowland Hopkins 1930 Karl Landsteiner 1931 Otto Warburg 1932 Charles Scott Sherrington
Charles Scott Sherrington
/ Edgar Adrian 1933 Thomas Morgan 1934 George Whipple
George Whipple
/ George Minot
George Minot
/ William Murphy 1935 Hans Spemann 1936 Henry Dale / Otto Loewi 1937 Albert Szent-Györgyi 1938 Corneille Heymans 1939 Gerhard Domagk 1940 1941 1942 1943 Henrik Dam
Henrik Dam
/ Edward Doisy 1944 Joseph Erlanger
Joseph Erlanger
/ Herbert Gasser 1945 Alexander Fleming
Alexander Fleming
/ Ernst Chain
Ernst Chain
/ Howard Florey 1946 Hermann Muller 1947 Carl Cori / Gerty Cori
Gerty Cori
/ Bernardo Houssay 1948 Paul Müller 1949 Walter Hess / António Egas Moniz 1950 Edward Kendall / Tadeusz Reichstein
Tadeusz Reichstein
/ Philip Hench

1951–1975

1951 Max Theiler 1952 Selman Waksman 1953 Hans Krebs / Fritz Lipmann 1954 John Enders / Thomas Weller / Frederick Robbins 1955 Hugo Theorell 1956 André Cournand / Werner Forssmann
Werner Forssmann
/ Dickinson W. Richards 1957 Daniel Bovet 1958 George Beadle / Edward Tatum
Edward Tatum
/ Joshua Lederberg 1959 Severo Ochoa
Severo Ochoa
/ Arthur Kornberg 1960 Frank Burnet / Peter Medawar 1961 Georg von Békésy 1962 Francis Crick
Francis Crick
/ James Watson
James Watson
/ Maurice Wilkins 1963 John Eccles / Alan Hodgkin / Andrew Huxley 1964 Konrad Bloch / Feodor Lynen 1965 François Jacob
François Jacob
/ André Lwoff / Jacques Monod 1966 Francis Rous / Charles B. Huggins 1967 Ragnar Granit
Ragnar Granit
/ Haldan Hartline / George Wald 1968 Robert W. Holley
Robert W. Holley
/ Har Khorana / Marshall Nirenberg 1969 Max Delbrück
Max Delbrück
/ Alfred Hershey
Alfred Hershey
/ Salvador Luria 1970 Bernard Katz / Ulf von Euler
Ulf von Euler
/ Julius Axelrod 1971 Earl Sutherland Jr. 1972 Gerald Edelman
Gerald Edelman
/ Rodney Porter 1973 Karl von Frisch
Karl von Frisch
/ Konrad Lorenz
Konrad Lorenz
/ Nikolaas Tinbergen 1974 Albert Claude
Albert Claude
/ Christian de Duve
Christian de Duve
/ George Palade 1975 David Baltimore
David Baltimore
/ Renato Dulbecco
Renato Dulbecco
/ Howard Temin

1976–2000

1976 Baruch Blumberg / Daniel Gajdusek 1977 Roger Guillemin / Andrew Schally
Andrew Schally
/ Rosalyn Yalow 1978 Werner Arber
Werner Arber
/ Daniel Nathans
Daniel Nathans
/ Hamilton O. Smith 1979 Allan Cormack / Godfrey Hounsfield 1980 Baruj Benacerraf / Jean Dausset
Jean Dausset
/ George Snell 1981 Roger Sperry / David H. Hubel
David H. Hubel
/ Torsten Wiesel 1982 Sune Bergström
Sune Bergström
/ Bengt I. Samuelsson / John Vane 1983 Barbara McClintock 1984 Niels Jerne / Georges Köhler / César Milstein 1985 Michael Brown / Joseph L. Goldstein 1986 Stanley Cohen / Rita Levi-Montalcini 1987 Susumu Tonegawa 1988 James W. Black / Gertrude B. Elion
Gertrude B. Elion
/ George H. Hitchings 1989 J. Michael Bishop
J. Michael Bishop
/ Harold E. Varmus 1990 Joseph Murray
Joseph Murray
/ E. Donnall Thomas 1991 Erwin Neher
Erwin Neher
/ Bert Sakmann 1992 Edmond Fischer / Edwin G. Krebs 1993 Richard J. Roberts
Richard J. Roberts
/ Phillip Sharp 1994 Alfred G. Gilman
Alfred G. Gilman
/ Martin Rodbell 1995 Edward B. Lewis
Edward B. Lewis
/ Christiane Nüsslein-Volhard
Christiane Nüsslein-Volhard
/ Eric F. Wieschaus 1996 Peter C. Doherty
Peter C. Doherty
/ Rolf M. Zinkernagel 1997 Stanley B. Prusiner 1998 Robert F. Furchgott
Robert F. Furchgott
/ Louis Ignarro
Louis Ignarro
/ Ferid Murad 1999 Günter Blobel 2000 Arvid Carlsson
Arvid Carlsson
/ Paul Greengard
Paul Greengard
/ Eric Kandel

2001–present

2001 Leland H. Hartwell / Tim Hunt
Tim Hunt
/ Paul Nurse 2002 Sydney Brenner
Sydney Brenner
/ H. Robert Horvitz / John E. Sulston 2003 Paul Lauterbur
Paul Lauterbur
/ Peter Mansfield 2004 Richard Axel
Richard Axel
/ Linda B. Buck 2005 Barry Marshall
Barry Marshall
/ Robin Warren 2006 Andrew Fire / Craig Mello 2007 Mario Capecchi
Mario Capecchi
/ Martin Evans
Martin Evans
/ Oliver Smithies 2008 Harald zur Hausen
Harald zur Hausen
/ Luc Montagnier
Luc Montagnier
/ Françoise Barré-Sinoussi 2009 Elizabeth Blackburn
Elizabeth Blackburn
/ Carol W. Greider
Carol W. Greider
/ Jack W. Szostak 2010 Robert G. Edwards 2011 Bruce Beutler
Bruce Beutler
/ Jules A. Hoffmann / Ralph M. Steinman (posthumously) 2012 John B. Gurdon
John B. Gurdon
/ Shinya Yamanaka 2013 James Rothman
James Rothman
/ Randy Schekman
Randy Schekman
/ Thomas C. Südhof 2014 John O'Keefe / May-Britt Moser
May-Britt Moser
/ Edvard Moser 2015 William C. Campbell / Satoshi Ōmura
Satoshi Ōmura
/ Tu Youyou 2016 Yoshinori Ohsumi 2017 Jeffrey C. Hall, Michael Rosbash, Michael W. Young

Authority control

WorldCat Identities VIAF: 57653984 ISNI: 0000 0000 1694 2677 GND: 1089941

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