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NM_001206615
NM_001206616
NM_012153

NM_007914

RefSeq (protein)

NP_001193544
NP_001193545
NP_036285

NP_031940

Location (UCSC) Chr 11: 34.62 – 34.66 Mb Chr 2: 103.26 – 103.3 Mb PubMed search [3] [4] Wikidata
View/Edit Human View/Edit Mouse

ETS homologous factor is a protein that in humans is encoded by the EHF gene.[5][6] This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis.[6]

Further reading

Cangemi, R., Mensah, A., Albertini, V., Jain, A., Mello-Grand, M., Chiorino, G., Catapano, C.V. & Carbone, G.M. Reduced expression and tumor suppressor function of the ETS transcription factor ESE-3 in prostate cancer. Oncogene 27, 2877-2885 (2008).

Albino D, Longoni N, Curti L, Mello-Grand M, Pinton S, Civenni G, Thalmann G, D'Ambrosio G, Sarti M, Sessa F, Chiorino G, Catapano CV, Carbone GM. ESE3/EHF controls epithelial cell differentiation and its loss leads to prostate tumors with mesenchymal and stem-like features. Cancer Res. 2012 Jun 1;72(11):2889-900.

Kunderfranco, P., Mello-Grand, M., Cangemi, R., Pellini, S., Mensah, A., Albertini, V., Malek, A., Chiorino, G., Catapano, C.V. & Carbone, G.M. ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer. PLoS One 5, e10547 (2010).

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135373 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000012350 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Kleinbaum LA, Duggan C, Ferreira E, Coffey GP, Buttice G, Burton FH (Nov 1999). "Human chromosomal localization, tissue/tumor expression, and regulatory function of the ets family gene EHF". Biochem Biophys Res Commun. 264 (1): 119–26. doi:10.1006/bbrc.1999.1493. PMID 10527851. 
  6. ^ a b "Entrez Gene: EHF ets homologous factor". 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.