EGIS-7625 is a selective and competitive 5-HT_2B receptor antagonist. It is experimentally proven to be directly associated with smooth stomach muscle constriction of white rats ''

in vivo Studies that are ''in vivo'' (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and ...

'', and variably effective in provoking a similar response in ''

in vitro ''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called " test-tube experiments", these studies in biology ...

'' human stomach cells. In high blood concentrations, it causes mild constriction of rabbit

pulmonary arteries A pulmonary artery is an artery in the pulmonary circulation that carries deoxygenated blood from the right side of the heart to the lungs. The largest pulmonary artery is the ''main pulmonary artery'' or ''pulmonary trunk'' from the heart, and ...

References

5-HT2 antagonists Anilines Piperazines {{nervous-system-drug-stub