EA-3167 is a potent and long-lasting

anticholinergic Anticholinergics (anticholinergic agents) are substances that block the action of the neurotransmitter called acetylcholine (ACh) at synapses in the central and peripheral nervous system. These agents inhibit the parasympathetic nervous system ...

deliriant Deliriants are a subclass of hallucinogen. The term was coined in the early 1980s to distinguish these drugs from psychedelics and dissociatives such as LSD and ketamine, respectively, due to their primary effect of causing delirium, as opposed t ...

drug, related to the

chemical warfare agent A chemical weapon (CW) is a specialized Ammunition, munition that uses chemicals chemical engineering, formulated to inflict death or harm on humans. According to the Organisation for the Prohibition of Chemical Weapons (OPCW), this can be an ...

3-quinuclidinyl benzilate 3-Quinuclidinyl benzilate (QNB) (IUPAC name 1-azabicyclo .2.2ctan-3-yl hydroxy(diphenyl)acetate; US Army code EA-2277; NATO code BZ; Soviet code Substance 78) is an odorless and bitter-tasting military incapacitating agent.QNB: Incapacitating Age ...

(QNB). It was developed under contract to

Edgewood Arsenal Aberdeen Proving Ground (APG) (sometimes erroneously called Aberdeen Proving ''Grounds'') is a U.S. Army facility located adjacent to Aberdeen, Harford County, Maryland, United States. More than 7,500 civilians and 5,000 military personnel work at ...

during the 1960s as part of the US military chemical weapons program, in an attempt to develop non-lethal

incapacitating agent The term incapacitating agent is defined by the United States Department of Defense as: :"An agent that produces temporary physiological or mental effects, or both, which will render individuals incapable of concerted effort in the performance o ...

s. EA-3167 has identical effects to QNB, but is even more potent and longer-lasting, with an effective dose when administered by injection of as little as 2.5 μg/kg (i.e. 0.2 milligrams for an 80 kg person), and a duration of 120–240 hours (5–10 days). However unlike QNB, EA-3167 was never weaponized or manufactured in bulk.

Stereoisomer In stereochemistry, stereoisomerism, or spatial isomerism, is a form of isomerism in which molecules have the same molecular formula and sequence of bonded atoms (constitution), but differ in the three-dimensional orientations of their atoms in ...

s of EA-3167 have also been synthesized under the codename HL-031120.

References

Deliriants Muscarinic antagonists Incapacitating agents 3-Quinuclidinyl esters Acetate esters Tertiary alcohols Phenylcyclopentylglycolate esters {{hallucinogen-stub

See also

References