Transcription factor E2F1 is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...

that in humans is encoded by the ''E2F1''

gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...

Function

The protein encoded by this gene is a member of the E2F family of

transcription factor In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The f ...

s. The E2F family plays a crucial role in the control of

cell cycle The cell cycle, or cell-division cycle, is the series of events that take place in a cell that cause it to divide into two daughter cells. These events include the duplication of its DNA (DNA replication) and some of its organelles, and sub ...

and action of

tumor suppressor A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell during cell division and replication. If the cell grows uncontrollably, it will result in cancer. When a tumor suppressor gene is mutated, it results in a loss or re ...

proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to

retinoblastoma protein The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated ''Rb'', ''RB'' or ''RB1'') is a proto-oncogenic tumor suppressor protein that is dysfunctional in several major cancers. One function of pRb is to prevent excessive ...

pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and

p53 p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often s ...

-dependent/independent apoptosis.

Transcription

E2F1 promoter AX8=> E2F1

Interactions

E2F1 has been shown to interact with: *

ARID3A AT-rich interactive domain-containing protein 3A is a protein that in humans is encoded by the ''ARID3A'' gene. Function This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homolo ...

, * CUL1, * Cyclin A1, *

Cyclin A2 Cyclin-A2 is a protein that in humans is encoded by the ''CCNA2'' gene. It is one of the two types of cyclin A: cyclin A1 is expressed during meiosis and embryogenesis while cyclin A2 is expressed in dividing somatic cells. Function Cyclin A2 ...

, *

GTF2H1 General transcription factor IIH subunit 1 is a protein that in humans is encoded by the ''GTF2H1'' gene. Interactions GTF2H1 has been shown to Protein-protein interaction, interact with: * Cyclin-dependent kinase 7, * E2F1, * ERCC2, * Est ...

, *

MDM4 Protein Mdm4 is a protein that in humans is encoded by the ''MDM4'' gene. Function The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization sig ...

, *

NCOA6 Nuclear receptor coactivator 6 is a protein that in humans is encoded by the ''NCOA6'' gene. Function The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcrip ...

, * NDN, * NPDC1, *

PURA Pura may refer to: Places * Pura, Kushtagi, a village in Koppal district, Karnataka, India * Pura, Iran, a village in Mazandaran Province, Iran * Pura, Tarlac, a municipality in the Philippines * Pura, Switzerland, a municipality in Ticino, S ...

, * PHB, * RB1, * RBL1, *

SKP2 S-phase kinase-associated protein 2 is an enzyme that in humans is encoded by the ''SKP2'' gene. Structure and function Skp2 contains 424 residues in total with the ~40 amino acid F-box domain lying closer to the N-terminal region at the 94-1 ...

, * SP1, * SP2, * SP3, * SP4, *

TFDP1 Transcription factor Dp-1 is a protein that in humans is encoded by the ''TFDP1'' gene. Function The E2F transcription factor family (see MIM 189971) regulates the expression of various cellular promoters, particularly those involved in the cel ...

* TOPBP1, *

TP53BP1 Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by the ''TP53BP1'' gene. Clinical significance 53BP1 is underexpressed in most cases of triple-negative breast cancer. ...

, and *

UBC The University of British Columbia (UBC) is a public research university with campuses near Vancouver and in Kelowna, British Columbia. Established in 1908, it is British Columbia's oldest university. The university ranks among the top three ...

References

External links

* * {{DEFAULTSORT:E2f1 Transcription factors

Function

Transcription

Interactions

See also

References

Further reading

External links