E-6801 is a
partial agonist
In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist. They may also be considered ligands which display both agonistic and antagonis ...
of the
5-HT6 receptor.
It enhanced recognition memory and reversed the memory deficits of
scopolamine in an object recognition task in a rat model.
The mechanism of memory enhancement is due to a combined modulation of
cholinergic
Cholinergic agents are compounds which mimic the action of acetylcholine and/or butyrylcholine. In general, the word "choline" describes the various quaternary ammonium salts containing the ''N'',''N'',''N''-trimethylethanolammonium cation. F ...
and
glutamatergic
Glutamatergic means "related to glutamate". A glutamatergic agent (or drug) is a chemical that directly modulates the excitatory amino acid (glutamate/aspartate) system in the body or brain. Examples include excitatory amino acid receptor agonis ...
neurotransmission.
See also
*
E-6837
E-6837 is an orally active, 5-HT6 agonist developed in an attempt to create an anti-obesity medication. In cell lines expressing rat 5-HT6 receptors, it acted as a partial agonist (on presumed silent receptors), while it acted as a full agonist ...
References
{{Tryptamines
5-HT6 agonists
Anorectics
Imidazoles
Chloroarenes
Sulfonamides
Thiazoles
Tryptamines