Dupee is a surname. Notable people with the surname include:
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Caroline Dupee Wade (1857–1947), American painter
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Dave Dupee (1916–2008), American professional basketball player
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F. W. Dupee (1904–1979), American literary critic
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Frank Dupee (1877–1956), American baseball player
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George Washington Dupee (1826–1897), American slave-turned-Baptist leader
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Kenneth Dupee Swan (1887–1970), American photographer
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Leonard Dupee White (1891–1958), American historian
*Michael George Dupée (born 1966), American game show contestant and author
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