Douglas L. Coleman (6 October 1931 – 16 April 2014) was a scientist and professor at

The Jackson Laboratory The Jackson Laboratory (often abbreviated as JAX) is an independent, non-profit biomedical research institution which was founded by a eugenicist. It employs more than 3,000 employees in Bar Harbor, Maine; Sacramento, California; Farmington, Con ...

, in

Bar Harbor Bar Harbor is a resort town on Mount Desert Island in Hancock County, Maine, United States. As of the 2020 census, its population is 5,089. During the summer and fall seasons, it is a popular tourist destination and, until a catastrophic fire i ...

, Maine. His work predicted that the ob gene encoded the

hormone A hormone (from the Greek participle , "setting in motion") is a class of signaling molecules in multicellular organisms that are sent to distant organs by complex biological processes to regulate physiology and behavior. Hormones are required ...

leptin Leptin (from Ancient Greek, Greek λεπτός ''leptos'', "thin" or "light" or "small") is a hormone predominantly made by adipose cells and enterocytes in the small intestine that helps to regulate Energy homeostasis, energy balance by inhib ...

, later co-discovered in 1994 by Jeffrey Friedman,

Rudolph Leibel Rudolph Leibel (born 1942) is the Christopher J. Murphy Professor of Diabetes Research, Professor of Pediatrics and Medicine at Columbia University Medical Center, and Director of the Division of Molecular Genetics in the Department of Pediatrics ...

and their research teams at

Rockefeller University The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classif ...

. This work has had a major role in our understanding of the mechanisms regulating body weight and that cause of

human Humans (''Homo sapiens'') are the most abundant and widespread species of primate, characterized by bipedalism and exceptional cognitive skills due to a large and complex brain. This has enabled the development of advanced tools, culture, ...

obesity Obesity is a medical condition, sometimes considered a disease, in which excess body fat has accumulated to such an extent that it may negatively affect health. People are classified as obese when their body mass index (BMI)—a person's we ...

. Coleman was born in

Stratford, Ontario Stratford is a city on the Avon River within Perth County in southwestern Ontario, Canada, with a 2016 population of 31,465 in a land area of . Stratford is the seat of Perth County, which was settled by English, Irish, Scottish and German im ...

. He obtained his BS degree from

McMaster University McMaster University (McMaster or Mac) is a public research university in Hamilton, Ontario, Canada. The main McMaster campus is on of land near the residential neighbourhoods of Ainslie Wood and Westdale, adjacent to the Royal Botanical Ga ...

in 1954 and his PhD in Biochemistry from the

University of Wisconsin A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States, t ...

in 1958. He was elected a member of the

US National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Natio ...

in 1998. He won the

Shaw Prize The Shaw Prize is an annual award presented by the Shaw Prize Foundation. Established in 2002 in Hong Kong, it honours "individuals who are currently active in their respective fields and who have recently achieved distinguished and signifi ...

in 2009, the

Albert Lasker Award for Basic Medical Research The Albert Lasker Award for Basic Medical Research is one of the prizes awarded by the Lasker Foundation for a fundamental discovery that opens up a new area of biomedical science. The award frequently precedes a Nobel Prize in Medicine; almost 5 ...

in 2010, the 2012

BBVA Foundation Frontiers of Knowledge Award The BBVA Foundation Frontiers of Knowledge Awards () are an international award programme recognizing significant contributions in the areas of scientific research and cultural creation. The categories that make up the Frontiers of Knowledge Awards ...

in the Biomedicine category and the 2013

King Faisal International Prize The King Faisal Prize ( ar, جائزة الملك فيصل, formerly King Faisal International Prize), is an annual award sponsored by King Faisal Foundation presented to "dedicated men and women whose contributions make a positive difference". T ...

for MedicineKing Faisal Prize 2013 for Medicine
/ref> jointly with Jeffrey M. Friedman for the discovery of leptin.

References

{{DEFAULTSORT:Coleman, Douglas L. Canadian biochemists University of Wisconsin–Madison College of Agricultural and Life Sciences alumni 1931 births 2014 deaths Members of the United States National Academy of Sciences Recipients of the Albert Lasker Award for Basic Medical Research McMaster University alumni Scientists from Ontario 20th-century Canadian scientists 21st-century Canadian scientists