Donald Pinkston Francis (born October 24, 1942) is an American

epidemiologist Epidemiology is the study and analysis of the distribution (who, when, and where), patterns and determinants of health and disease conditions in a defined population. It is a cornerstone of public health, and shapes policy decisions and evidenc ...

who worked on the Ebola outbreak in Africa in the late 1970s, and as an

HIV/AIDS research HIV/AIDS research includes all medical research that attempts to prevent, treat, or cure HIV/AIDS, as well as fundamental research about the nature of HIV as an infectious agent and AIDS as the disease caused by HIV. Transmission A body of sc ...

er. He retired from the U.S. Public Health Service in 1992, after 21 years of service. He lives in

San Francisco, California San Francisco (; Spanish for " Saint Francis"), officially the City and County of San Francisco, is the commercial, financial, and cultural center of Northern California. The city proper is the fourth most populous in California and 17th ...

Early life

Francis was born October 24, 1942 in the

San Francisco Bay Area The San Francisco Bay Area, often referred to as simply the Bay Area, is a populous region surrounding the San Francisco, San Pablo, and Suisun Bay estuaries in Northern California. The Bay Area is defined by the Association of Bay Area Go ...

California California is a state in the Western United States, located along the Pacific Coast. With nearly 39.2million residents across a total area of approximately , it is the most populous U.S. state and the 3rd largest by area. It is also the m ...

and grew up in Marin County. His main interest was

skiing Skiing is the use of skis to glide on snow. Variations of purpose include basic transport, a recreational activity, or a competitive winter sport. Many types of competitive skiing events are recognized by the International Olympic Committee ( ...

, and his mother, father and grandfather were physicians. However, he was a poor student as a child, suffering from dyslexia. Francis has said that he gravitated towards science because he had such difficulty with subjects where fluent reading ability was needed. Francis completed his undergraduate studies at the

University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant u ...

, where he was a member of the California chapter at

Delta Upsilon Delta Upsilon (), commonly known as DU, is a collegiate men's fraternity founded on November 4, 1834 at Williams College in Williamstown, Massachusetts. It is the sixth-oldest, all-male, college Greek Letter Organizations#Greek letters, Greek-let ...

, class of 1966. He received his M.D. from

Northwestern University Northwestern University is a private research university in Evanston, Illinois. Founded in 1851, Northwestern is the oldest chartered university in Illinois and is ranked among the most prestigious academic institutions in the world. Charte ...

and his Doctor of Science in Virology from Harvard. An infectious diseases fellowship at Harvard followed his internship and residency in pediatrics at the University of California Medical Center in

Los Angeles Los Angeles ( ; es, Los Ángeles, link=no , ), often referred to by its initials L.A., is the List of municipalities in California, largest city in the U.S. state, state of California and the List of United States cities by population, sec ...

. Francis helped eradicate

smallpox Smallpox was an infectious disease caused by variola virus (often called smallpox virus) which belongs to the genus Orthopoxvirus. The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) c ...

from Sudan,

India India, officially the Republic of India (Hindi: ), is a country in South Asia. It is the seventh-largest country by area, the second-most populous country, and the most populous democracy in the world. Bounded by the Indian Ocean on the so ...

and

Bangladesh Bangladesh (}, ), officially the People's Republic of Bangladesh, is a country in South Asia. It is the eighth-most populous country in the world, with a population exceeding 165 million people in an area of . Bangladesh is among the mos ...

before working on AIDS. He worked on the cholera epidemic in

Nigeria Nigeria ( ), , ig, Naìjíríyà, yo, Nàìjíríà, pcm, Naijá , ff, Naajeeriya, kcg, Naijeriya officially the Federal Republic of Nigeria, is a country in West Africa. It is situated between the Sahel to the north and the Gulf o ...

in the early 1970s, the smallpox epidemic in Yugoslavia in 1972, and the 1976 Ebola epidemic in Sudan. In addition, Francis was an early developer of the

hepatitis B Hepatitis B is an infectious disease caused by the '' Hepatitis B virus'' (HBV) that affects the liver; it is a type of viral hepatitis. It can cause both acute and chronic infection. Many people have no symptoms during an initial infection. ...

vaccine in the United States and China.

Later work

Francis began his work on AIDS in 1981. He was one of the first scientists to suggest that AIDS was caused by an infectious agent. As director of the CDC's AIDS Laboratory Activities, he worked closely with the

Institut Pasteur The Pasteur Institute (french: Institut Pasteur) is a French non-profit private foundation dedicated to the study of biology, micro-organisms, diseases, and vaccines. It is named after Louis Pasteur, who invented pasteurization and vaccines f ...

which isolated

HIV The human immunodeficiency viruses (HIV) are two species of ''Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune ...

. At the time of his retirement from the CDC, he was the centers' AIDS Advisor to the State of California and Special Consultant to Mayor

Art Agnos Arthur Christ Agnos (born Arthouros Agnos; [] September 1, 1938) is an American politician. He served as the 39th Mayor of San Francisco, mayor of San Francisco, California from 1988 to 1992 and as the Regional Head of the United States Department ...

in San Francisco. In the latter capacity he served as the Chair of the Mayor's HIV Task Force. In 1993, Francis joined Genentech, Inc., of South San Francisco to try to develop a

vaccine A vaccine is a biological preparation that provides active acquired immunity to a particular infectious or malignant disease. The safety and effectiveness of vaccines has been widely studied and verified.

for HIV. In 1995, Francis and fellow retro-virologist Dr. Robert Nowinski spun off Genentech's HIV vaccine unit after the company had disappointing results, and founded VaxGen, based in Brisbane, California, to continue working on vaccines. After the vaccine failed in clinical trials, Francis left VaxGen in 2004 to co-found Global Solutions for Infectious Diseases, where he serves as executive director and principal investigator.

''And The Band Played On''

In 1993, HBO produced ''

And The Band Played On ''And the Band Played On: Politics, People, and the AIDS Epidemic'' is a 1987 book by ''San Francisco Chronicle'' journalist Randy Shilts. The book chronicles the discovery and spread of the human immunodeficiency virus (HIV) and acquired immun ...

'', an Emmy-winning movie about the AIDS crisis based on the 1987 book of the same name by ''

San Francisco Chronicle The ''San Francisco Chronicle'' is a newspaper serving primarily the San Francisco Bay Area of Northern California. It was founded in 1865 as ''The Daily Dramatic Chronicle'' by teenage brothers Charles de Young and Michael H. de Young. The ...

'' journalist

Randy Shilts Randy Shilts (August 8, 1951February 17, 1994) was an American journalist and author. After studying journalism at the University of Oregon, Shilts began working as a reporter for both '' The Advocate'' and the ''San Francisco Chronicle'', as wel ...

. Actor

Matthew Modine Matthew Avery Modine (born March 22, 1959) is an American actor and filmmaker, who rose to prominence through his role as U.S. Marine Private/Sergeant J.T. "Joker" Davis in ''Full Metal Jacket''. His other film roles include the title character ...

plays Francis, a central figure in the movie. In both the book and the film, his antagonist is Dr.

Robert Gallo Robert Charles Gallo (; born March 23, 1937) is an American biomedical researcher. He is best known for his role in establishing the human immunodeficiency virus (HIV) as the infectious agent responsible for acquired immune deficiency syndrome ...

(portrayed in the film by

Alan Alda Alan Alda (; born Alphonso Joseph D'Abruzzo; January 28, 1936) is an American actor, screenwriter, and director. A six-time Emmy Award and Golden Globe Award winner, he is best known for playing Captain Benjamin "Hawkeye" Pierce in the war come ...

), the discoverer of

HTLV The human T-lymphotropic virus, human T-cell lymphotropic virus, or human T-cell leukemia-lymphoma virus (HTLV) family of viruses are a group of human retroviruses that are known to cause a type of cancer called adult T-cell leukemia/lymphoma an ...

(the human T-cell leukemia virus), who cuts off assistance when he hears that Francis has shared some experimental materials with

Françoise Barré-Sinoussi (; born 30 July 1947) is a French virologist and Director of the Regulation of Retroviral Infections Division (french: Unité de Régulation des Infections Rétrovirales) and Professor at the in Paris, France. Born in Paris, France, Barré-Sino ...

and Luc Montagnier (portrayed in the film by

Nathalie Baye Nathalie Marie Andrée Baye (born 6 July 1948) is a French film, television and stage actress. She began her career in 1970 and has appeared in more than 80 films. A ten-time César Award nominee, her four wins were for '' Every Man for Himself'' ...

and Patrick Bauchau), the French researchers at the Pasteur Institute who were given the Nobel Prize for their discovery of the HIV virus.

Early life

Later work

''And The Band Played On''

References

Further reading