Dexloxiglumide is a drug which acts as a
cholecystokinin antagonist A cholecystokinin receptor antagonist is a specific type of receptor antagonist which blocks the receptor sites for the peptide hormone cholecystokinin ( CCK).
There are two subtypes of this receptor known at present, defined as CCKA and CCKB (a ...
, selective for the
CCKA subtype. It inhibits gastrointestinal motility and reduces gastric secretions, and despite older selective CCK
A antagonists such as
lorglumide
Lorglumide (CR-1409) is a drug which inhibits gastrointestinal motility and reduces gastric secretions, acting as a cholecystokinin antagonist, with fairly high selectivity for the CCKA subtype. It has been suggested as a potential treatment for ...
and
devazepide having had only limited success in trials and ultimately never making it into clinical use, dexloxiglumide is being investigated as a potential treatment for a variety of gastrointestinal problems including
irritable bowel syndrome
Irritable bowel syndrome (IBS) is a "disorder of gut-brain interaction" characterized by a group of symptoms that commonly include abdominal pain and or abdominal bloating and changes in the consistency of bowel movements. These symptoms may ...
,
dyspepsia
Indigestion, also known as dyspepsia or upset stomach, is a condition of impaired digestion. Symptoms may include upper abdominal fullness, heartburn, nausea, belching, or upper abdominal pain. People may also experience feeling full earlier ...
,
constipation
Constipation is a bowel dysfunction that makes bowel movements infrequent or hard to pass. The stool is often hard and dry. Other symptoms may include abdominal pain, bloating, and feeling as if one has not completely passed the bowel moveme ...
and
pancreatitis
Pancreatitis is a condition characterized by inflammation of the pancreas. The pancreas is a large organ behind the stomach that produces digestive enzymes and a number of hormones. There are two main types: acute pancreatitis, and chronic p ...
,
[{{cite journal , vauthors = Barrett TD, Yan W, Freedman JM, Lagaud GJ, Breitenbucher JG, Shankley NP , title = Role of CCK and potential utility of CCK1 receptor antagonism in the treatment of pancreatitis induced by biliary tract obstruction , journal = British Journal of Pharmacology , volume = 153 , issue = 8 , pages = 1650–8 , date = April 2008 , pmid = 18297100 , pmc = 2438255 , doi = 10.1038/bjp.2008.44 ] and has had moderate success so far although trials are still ongoing.
References
Cholecystokinin antagonists
Chloroarenes
Benzamides
Ethers