Daprodustat, sold under the brand name Duvroq among others, is a
medication
A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy ( pharmacotherapy) is an important part of the medical field and ...
that is used for the treatment of
anemia
Anemia or anaemia (British English) is a blood disorder in which the blood has a reduced ability to carry oxygen due to a lower than normal number of red blood cells, or a reduction in the amount of hemoglobin. When anemia comes on slowly, t ...
due to
chronic kidney disease.
It is a
hypoxia-inducible factor prolyl hydroxylase inhibitor.
It is taken
by mouth
Oral administration is a route of administration where a substance is taken through the mouth. Per os abbreviated to P.O. is sometimes used as a direction for medication to be taken orally. Many medications are taken orally because they are i ...
.
The most common side effects include high blood pressure, thrombotic vascular events, abdominal pain, dizziness and allergic reactions.
Daprodustat was approved for medical use in Japan in June 2020, and in the United States in February 2023.
[ ] It is the first oral treatment for anemia caused by chronic kidney disease for adults.
Medical uses
Daprodustat is
indicated
In medicine, an indication is a valid reason to use a certain test, medication, procedure, or surgery. There can be multiple indications to use a procedure or medication. An indication can commonly be confused with the term diagnosis. A diagnosis ...
for the treatment of anemia due to chronic kidney disease.
History
Daprodustat increases erythropoietin levels.
The effectiveness of daprodustat was established in a randomized study of 2,964 adult participants receiving dialysis.
In this study, participants received either oral daprodustat or injected recombinant human erythropoietin (a standard of care treatment for people with anemia due to chronic kidney disease).
Daprodustat raised and maintained the hemoglobin (the protein in red blood cells that carries oxygen and is a common measure of anemia) within the target range of 10-11 grams/deciliter, similar to that of the recombinant human erythropoietin.
The US
Food and Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respon ...
(FDA) granted the approval of Jesduvroq to GlaxoSmithKline LLC.
Society and culture
Due to its potential applications in
athletic doping
In competitive sports, doping is the use of banned athletic performance-enhancing drugs by athletic competitors as a way of cheating in sports. The term ''doping'' is widely used by organizations that regulate sporting competitions. The use of ...
, it has also been incorporated into screens for
performance-enhancing drugs
Performance-enhancing substances, also known as performance-enhancing drugs (PEDs), are substances that are used to improve any form of activity performance in humans. A well-known example of cheating in sports involves doping in sport, where bann ...
.
Research
Daprodustat is in phase III clinical trials for the treatment of
anemia
Anemia or anaemia (British English) is a blood disorder in which the blood has a reduced ability to carry oxygen due to a lower than normal number of red blood cells, or a reduction in the amount of hemoglobin. When anemia comes on slowly, t ...
caused by
chronic kidney disease.
References
External links
*
Acetic acids
Cyclohexyl compounds
GSK plc brands
Pyrimidinediones
{{blood-drug-stub