Daniela Bargellini Rhodes FRS (born 1946) is an Italian structural and molecular biologist. She was a senior scientist at the

Laboratory of Molecular Biology The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical r ...

Cambridge Cambridge ( ) is a university city and the county town in Cambridgeshire, England. It is located on the River Cam approximately north of London. As of the 2021 United Kingdom census, the population of Cambridge was 145,700. Cambridge bec ...

, England, where she worked, and later studied for her PhD under the supervision of Nobel laureate

Aaron Klug Sir Aaron Klug (11 August 1926 – 20 November 2018) was a British biophysicist and chemist. He was a winner of the 1982 Nobel Prize in Chemistry for his development of crystallographic electron microscopy and his structural elucidation of bio ...

. Continuing her work under the tutelage of

, she was appointed group leader in 1983, obtained tenure in 1987 and was promoted to senior scientist in 1994 (equivalent to full professor). Subsequently, she served as director of studies between 2003 and 2006. She has also been visiting professor at both "

La Sapienza The Sapienza University of Rome ( it, Sapienza – Università di Roma), also called simply Sapienza or the University of Rome, and formally the Università degli Studi di Roma "La Sapienza", is a public research university located in Rome, Ita ...

" in Rome, Italy and the

Rockefeller University The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classif ...

in NY, USA.

Career and research

Daniela Rhodes has made many fundamental contributions to understanding the structure and function of nucleic acids and their biologically important interactions with many different proteins. Her work combines biochemical analyses with direct structural determination. She determined the structures of a number of important protein-DNA complexes involved in transcription, such as zinc-fingers and nuclear hormone receptors. She has provided some of the first structural information on telomeric proteins, such as yeast Rap1p and human

TRF1 The TRF1 is a 155mm French towed howitzer produced by Nexter (ex Giat Industries) and used by the French Army. The TRF1 was showcased in 1979 at the Eurosatory arms trade show, as a replacement for Armée de Terre's BF-50. Giat produced it fro ...

and TRF2 and their complexes with DNA. Throughout her career she has made many contributions to the understanding of chromatin structure and function. She was involved in determining the structure of the nucleosome core particle, has worked on transcriptionally active

chromatin Chromatin is a complex of DNA and protein found in eukaryote, eukaryotic cells. The primary function is to package long DNA molecules into more compact, denser structures. This prevents the strands from becoming tangled and also plays important ...

and more recently on the higher order 30nm structure of chromatin. Her research continues to focus on understanding how the structure of

is involved in

transcriptional regulation In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA ( transcription), thereby orchestrating gene activity. A single gene can be regulated in a range of ways, from ...

and how

telomeres A telomere (; ) is a region of repetitive nucleotide sequences associated with specialized proteins at the ends of linear chromosomes. Although there are different architectures, telomeres, in a broad sense, are a widespread genetic feature mos ...

are involved in preserving chromosome integrity. She joined the School of Biological Sciences at

Nanyang Technological University The Nanyang Technological University (NTU) is a national research university in Singapore. It is the second oldest autonomous university in the country and is considered as one of the most prestigious universities in the world by various in ...

(NTU), in Singapore, as professor in September 2011 and was additionally appointed professor at the Lee Kong Chian School of Medicine in September 2012. In April 2014 she was appointed Director of the newly formed Nanyang Institute of Structural Biology.

Awards and honours

* Elected a Fellow of the Royal Society (FRS) in 2007 * Elected member of

EMBO Embo ( gd, Eurabol, IPA: �iaɾəpɔɫ̪ is a village in the Highland Council Area in Scotland and the former postal county of Sutherland, about north-northeast of Dornoch. On 16 July 1988, Embo declared itself independent from the rest of the ...

as of 1996. * Elected member of

Academia Europaea The Academia Europaea is a pan-European Academy of Humanities, Letters, Law, and Sciences. The Academia was founded in 1988 as a functioning Europe-wide Academy that encompasses all fields of scholarly inquiry. It acts as co-ordinator of Europea ...

as of 2011. * She is a Fellow of

Clare Hall, Cambridge Clare Hall is a constituent college of the University of Cambridge, England. Founded in 1966 by Clare College, Clare Hall is a college for advanced study, admitting only postgraduate students alongside postdoctoral researchers and fellows. It ...

. * Asteroid 80008 Danielarhodes, discovered by Italian astronomers

Luciano Tesi Luciano Tesi (; born 10 December 1931) is an Italian veterinarian, amateur astronomer, discoverer of many minor planets, and director of the San Marcello Pistoiese Observatory. In 1980, he founded the "Amateur Group of Pistoiese Mountain" ( it, ...

and

Andrea Boattini Andrea Boattini (born 16 September 1969) is an Italian astronomer and a prolific discoverer of minor planets and comets. Career After developing a growing interest in minor planets, he graduated in 1996 from the University of Bologna with a ...

in 1999, was named in her honor. The official was published by the

Minor Planet Center The Minor Planet Center (MPC) is the official body for observing and reporting on minor planets under the auspices of the International Astronomical Union (IAU). Founded in 1947, it operates at the Smithsonian Astrophysical Observatory. Function T ...

on 10 December 2011 ().

References

{{DEFAULTSORT:Rhodes, Daniela Female Fellows of the Royal Society Living people Place of birth missing (living people) British women scientists British molecular biologists Fellows of Clare Hall, Cambridge Alumni of the University of Cambridge Members of the European Molecular Biology Organization Academics of the University of Cambridge Rockefeller University faculty Fellows of the Royal Society Academic staff of Nanyang Technological University 1946 births