Dalla Lana School of Public Health

Dalla Lana School of Public Health is the school of public health at the University of Toronto. It was founded in 1927, and was home for 50 years to Connaught Laboratories, a manufacturer of vaccines, insulin, and many other pharmaceutical products. Having grown to be the largest cluster of public health scholars in Canada, the school was revitalized in 2008 with the support of a major gift from the Dalla Lana family.

Early history

Hygiene, particularly sanitation, was a component of the teaching programs at the early private medical schools in Toronto starting as early as 1871. One of the earliest recorded hygiene instructors was William Coverton, who taught sanitary sciences in the Trinity University medical school from 1878–1891. At the competing Toronto School of Medicine in the mid 1880s, William Oldright, a physician and sanitarian who served as the first chair of the Ontario Provincial Board of Health, lectured in the sanitary sciences. Following the merger of the Toronto School of Medicine with the University of Toronto, Oldright continued to teach sanitation sciences in the Faculty of Medicine and chair the Department of Hygiene until his retirement in 1910. During his tenure, Oldright established a museum of hygiene in the basement of the medical building that showcased technological developments ranging from sewage management to ventilation, water testing and personal protective equipment for workers.

Upon Oldright's retirement, John Amyot, a bacteriologist affiliated with the provincial health laboratory, was appointed chair of the Department of Hygiene and Sanitary Science in Faculty of Medicine. Like Oldright, Amyot was interested in sewage treatment and water treatment as means of controlling diseases such as typhoid. From his experience as a physician, Amyot was also a strong proponent of preventive medicine. Together with then-Medical Officer of Health JWS McCullough and Professor of Biology Robert Ramsay Wright, Amyot championed the creation of a Diploma in Public Health (DPH), emphasizing sanitation but including training in bacteriology and preventive medicine. The program was first offered in 1912, and its first graduate, Robert Defries, completed training in 1913 under Amyot's supervision.

John FitzGerald and the Antitoxin Laboratory

John G. FitzGerald completed his medical training at the University of Toronto in 1903. After spending time as a ship's physician, FitzGerald studied psychiatry in Buffalo, New York and neurology at Johns Hopkins University and bacteriology at Harvard University with brief stints abroad at the Pasteur Institute and the University of Freiburg. Upon his return to North America in 1911, FitzGerald accepted an appointment as Associate Professor of bacteriology at the University of California Berkeley – a position he held until Amyot recruited him to return to Toronto in 1913 as the first full-time faculty member of the Department of Hygiene. FitzGerald's experience in Europe made him aware of the success of antitoxins and vaccines as a means of reducing mortality. Needing laboratory space when he arrived in Toronto, FitzGerald set up to work in the Provincial Board of Health laboratory at 4 Queen's Park where he began preparing rabies vaccine using the method of Louis Pasteur, successfully eliminating its costly, daily purchase from suppliers in New York.

Capitalizing on the success of his rabies venture, FitzGerald set out to address the much larger problem of diphtheria. Despite Paul Ehrlich's demonstration of the effectiveness of diphtheria antitoxin in the 1890s, the treatment remained slowly adopted on wider scale and diphtheria deaths in children continued to rise well into early decades of the 1900s. In 1914, Fitzgerald approached the University's Board of Governors proposing a plan to create a "Serum Institute" whose purpose was to manufacture and sell diphtheria and other antitoxins through the Department of Hygiene, providing them to Provincial Health Departments across Canada for distribution. FitzGerald's proposal also included the development of a research program focused on the prevention or treatment of a range of other infectious diseases, and the close integration of commercial and research activities with the department's teaching programs. FitzGerald's idea won approval from the Board of Governors and, with the support of Amyot, he began in 1914 to develop space in the medical building made available by the decommissioning of Oldright's museum. As diphtheria antibodies needed to be raised in horses, stabling provisions were also required. Amyot's assistant, William Fenton, proposed their accommodation in a small stable behind his home at 145 Barton Avenue near the university.
Despite the military service of FitzGerald and Amyot, the activities of the Antitoxin Laboratory continued during the First World War although its focus had shifted to the production of tetanus vaccine in support of the overseas war effort. In 1915, Defries was appointed to lead the tetanus program which he did until called away by military obligations in 1916. Like diphtheria, tetanus vaccine manufacture also used horses to raise polyclonal antibodies. The rapid expansion of the antitoxin program quickly overwhelmed the capacity of Fenton's barn and the generously donated stables of the decommissioned Ontario Veterinary College buildings on Temperance Street, presenting an urgent space need.

Connaught Laboratories

In 1915, the chair of the Ontario chapter of the Red Cross, Colonel Albert Gooderham

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