Dihydropyrimidinase is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products ...
that in humans is encoded by the ''DPYS''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Dihydropyrimidinase catalyzes the conversion of
5,6-dihydrouracil to
3-ureidopropionate in
pyrimidine metabolism
Pyrimidine biosynthesis occurs both in the body and through organic synthesis.
''De novo'' biosynthesis of pyrimidine
''De Novo'' biosynthesis of a pyrimidine is catalyzed by three gene products CAD, DHODH and UMPS. The first three enzymes of ...
. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to
dihydropyrimidinuria.
Interactive pathway map
References
Further reading
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