DOV 216,303 is an experimental antidepressant drug originally developed by

DOV Pharmaceutical DOV Pharmaceutical was a biotechnology company that focused on therapies primarily for central nervous system conditions. It was founded in 1995 by former employees of American Cyanamid (which was acquired by Wyeth in 1994), and in 1998 it in-lic ...

and was licensed to Merck & Co. in 2004; Merck and DOV terminated their relationship in December 2006. It is a triple reuptake inhibitor (TRI), or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). It is the

racemic In chemistry, a racemic mixture, or racemate (), is one that has equal amounts of left- and right-handed enantiomers of a chiral molecule or salt. Racemic mixtures are rare in nature, but many compounds are produced industrially as racemates. ...

mixture of amitifadine (DOV-21,947) and its (–)- enantiomer, DOV-102,677. Its IC₅₀ values for SERT,

NET Net or net may refer to: Mathematics and physics * Net (mathematics), a filter-like topological generalization of a sequence * Net, a linear system of divisors of dimension 2 * Net (polyhedron), an arrangement of polygons that can be folded up ...

, and DAT are K_i 14 nM, 20 nM, and 78 nM, respectively. As of March 2008, DOV had no intention to further develop DOV-216,303 because the patent on the compound had expired. In a

mouse model A model organism (often shortened to model) is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the working ...

, DOV-216,303 has shown the ability to promote recovery after spinal cord

contusion A bruise, also known as a contusion, is a type of hematoma of tissue, the most common cause being capillaries damaged by trauma, causing localized bleeding that extravasates into the surrounding interstitial tissues. Most bruises occur clos ...

References

{{Monoamine reuptake inhibitors Chloroarenes Serotonin–norepinephrine–dopamine reuptake inhibitors Abandoned drugs

See also

References