DNA polymerase delta (DNA Pol δ) is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products ...
complex found in
eukaryote
Eukaryotes () are organisms whose cells have a nucleus. All animals, plants, fungi, and many unicellular organisms, are Eukaryotes. They belong to the group of organisms Eukaryota or Eukarya, which is one of the three domains of life. Bacter ...
s that is involved in
DNA replication
In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule. DNA replication occurs in all living organisms acting as the most essential part for biological inheritan ...
and
repair
The technical meaning of maintenance involves functional checks, servicing, repairing or replacing of necessary devices, equipment, machinery, building infrastructure, and supporting utilities in industrial, business, and residential installa ...
. The DNA polymerase delta complex consists of 4 subunits:
POLD1,
POLD2,
POLD3, and
POLD4.
DNA Pol δ is an enzyme used for both leading and lagging strand synthesis.
It exhibits increased processivity when interacting with the proliferating cell nuclear antigen (
PCNA). As well, the multisubunit protein
replication factor C
The replication factor C, or RFC, is a five-subunit protein complex that is required for DNA replication.
The subunits of this heteropentamer are named Rfc1, Rfc2, Rfc3, Rfc4, and Rfc5 in ''Saccharomyces cerevisiae''. RFC is used in eukaryo ...
, through its role as the clamp loader for PCNA (which involves catalysing the loading of PCNA on to DNA) is important for DNA Pol δ function.
References
External links
*
EC 2.7.7
DNA replication
DNA repair
DNA-binding proteins
{{2.7-enzyme-stub