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NM_080797

NM_001291432
NM_001291433
NM_011805
NM_175551
NM_177852

RefSeq (protein)

NP_001278361
NP_001278362
NP_035935
NP_780760
NP_808520

Location (UCSC) Chr 20: 62.88 – 62.94 Mb Chr 2: 180.66 – 180.71 Mb PubMed search [3] [4] Wikidata
View/Edit Human View/Edit Mouse

Death-inducer obliterator 1 is a protein that in humans is encoded by the DIDO1 gene.[5][6]

Function

Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms.[6]

References

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.