DHA-clozapine (tentative trade name Clozaprexin) is an atypical

antipsychotic Antipsychotics, also known as neuroleptics, are a class of psychotropic medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia but also in a range of ...

drug candidate that was created and originally tested by chemists at Protarga, a small pharmaceutical in Pennsylvania, and scientists at Harvard University. It is a prodrug of

clozapine Clozapine is a psychiatric medication and is the first atypical antipsychotic (also called second-generation antipsychotic). It is primarily used to treat people with schizophrenia and schizoaffective disorders who have had an inadequate respo ...

; the fatty acid

docosahexaenoic acid Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina. In physiological literature, it is given the name 22:6(n-3). It can be synthesized from alpha-lin ...

(DHA) was added to clozapine in order to increase penetration of the blood–brain barrier. Protarga was purchased by Luitpold Pharmaceuticals in 2003 and development was discontinued in 2007.

References

Atypical antipsychotics Chloroarenes Dibenzodiazepines Dopamine antagonists Piperazines Prodrugs Serotonin receptor antagonists Abandoned drugs {{nervous-system-drug-stub