Concentrative nucleoside transporters
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Human concentrative nucleoside transporters include
SLC28A1 Concentrative nucleoside transporter 1 (CNT1) is a protein that in humans is encoded by the ''SLC28A1'' gene. See also * Concentrative nucleoside transporters * Nucleoside transporter Nucleoside transporters (NTs) are a group of membrane tra ...
,
SLC28A2 Concentrative nucleoside transporter 2 (CNT2) is a protein that in humans is encoded by the ''SLC28A2'' gene. See also * Concentrative nucleoside transporters * Nucleoside transporter Nucleoside transporters (NTs) are a group of membrane tra ...
and
SLC28A3 SLC may refer to: Places * Salt Lake City, Utah * Salt Lake City International Airport, IATA Airport Code Education * Sarah Lawrence College, NY * School Leaving Certificate (Nepal) * St. Lawrence College, Ontario, Canada * Small Learning Com ...
proteins. SLC28A2 is a purine-specific Na+-nucleoside cotransporter localised to the bile canalicular
membrane A membrane is a selective barrier; it allows some things to pass through but stops others. Such things may be molecules, ions, or other small particles. Membranes can be generally classified into synthetic membranes and biological membranes. ...
. SLC28A1 is a Na+-dependent nucleoside transporter selective for pyrimidine
nucleosides Nucleosides are glycosylamines that can be thought of as nucleotides without a phosphate group. A nucleoside consists simply of a nucleobase (also termed a nitrogenous base) and a five-carbon sugar ( ribose or 2'-deoxyribose) whereas a nucleot ...
and adenosine. It also transports the anti-viral nucleoside analogues
Zidovudine Zidovudine (ZDV), also known as azidothymidine (AZT), is an antiretroviral medication used to prevent and treat HIV/AIDS. It is generally recommended for use in combination with other antiretrovirals. It may be used to prevent mother-to-child ...
and
Zalcitabine Zalcitabine (2′-3′-di deoxycytidine, ddC), also called dideoxycytidine, is a nucleoside analog reverse-transcriptase inhibitor (NRTI) sold under the trade name Hivid. Zalcitabine was the third antiretroviral to be approved by the Food and Drug ...
.


References

{{InterPro content, IPR011657 Protein families Transmembrane transporters