Clofibride is a

fibrate In pharmacology, the fibrates are a class of amphipathic carboxylic acids and esters. They are derivatives of fibric acid (phenoxyisobutyric acid). They are used for a range of metabolic disorders, mainly hypercholesterolemia (high cholesterol), ...

. Clofibride is a derivative of

clofibrate Clofibrate (trade name Atromid-S) is a lipid-lowering agent used for controlling the high cholesterol and triacylglyceride level in the blood. It belongs to the class of fibrates. It increases lipoprotein lipase activity to promote the conversion ...

. In the body it is converted into 4-chlorophenoxyisobutyric acid (

clofibric acid Clofibric acid is a biologically active metabolite of the lipid-lowering drugs clofibrate, etofibrate and theofibrate with the molecular formula C10H11ClO3. It has been found in the environment following use of these drugs, for example in Swiss ...

), which is the true

hypolipidemic agent Lipid-lowering agents, also sometimes referred to as hypolipidemic agents, cholesterol-lowering drugs, or antihyperlipidemic agents are a diverse group of pharmaceuticals that are used to lower the level of lipids and lipoproteins such as cholestero ...

. So clofibride, just like clofibrate is a prodrug of clofibric acid.

References

2-Methyl-2-phenoxypropanoic acid derivatives Prodrugs Chloroarenes Carboxamides {{cardiovascular-drug-stub