NHS Foundation Trust is located in Withington,
Manchester, and is one of the largest cancer treatment centres in
Europe. The Christie became a
NHS Foundation Trust in April 2007 and
is also an international leader in cancer research and development,
and home to the Paterson Institute for
1.1 Foundation of the Christie Hospital
1.2 Foundation of the Holt Institute
1.3 The Christie at Withington
Cancer Research UK
Manchester Institute (former Paterson Institute
2.1 Private patients
3 Foundation Trust
5 Fire incident
6 See also
8 External links
Foundation of the Christie Hospital
The hospital had its beginnings in the largesse of Sir Joseph
Whitworth, a wealthy Mancunian inventor who left money in his will in
1887. He wanted this to be spent on good causes in
entrusted his bequest to three legatees, one of whom was Richard
Copley Christie. Consequently, some of that money was used to buy
land off Oxford Road, adjacent to
Owens College and intended to allow
the movement of the central
Manchester hospitals out of the crowded
city centre. A committee chaired by Christie was established in
1890 and, partly funded by a legacy of £10,000 from Daniel Proctor, a
Cancer Pavilion and Home for Incurables was founded on the site in
1892 some distance south-east of the eye hospital. In 1901 it was
renamed the Christie Hospital in honour of Richard Christie and his
wife Mary. It was the only hospital outside London for the
treatment of cancer alone and active in pathological research.
Foundation of the Holt Institute
In 1901, the Christie Management Committee agreed to the request of Dr
Robert Biggs Wild to spend £50 on the equipment necessary to test the
X ray treatment, after promising results reported from
London and from three patients treated in the Physics Laboratory of
Professor Schuster locally in Owens College. The Roentgen apparatus
was purchased, but no records survive of treatment, and by 1907 the
equipment was no longer being used (it was given to the Skin Hospital
in 1910). By 1905, Dr Wild had become interested in the therapeutic
use of the newly discovered radium and experimented, once more with
aid from Professor Schuster, on three patients.
Radium was expensive,
however, and the management refused to purchase any more until the
results of tests from London hospitals were available. By 1914, a
leading local doctor, Sir William Milligan, had begun a campaign in
Manchester Guardian' to raise funds for radium treatment.
Appealing to a mixture of local pride and the contemporary enthusiasm
for the curative powers of radium, an appeal was launched, on the
advice of Ernest Rutherford, for £25,000. An initial contribution of
£2000 from local brewer Edward Holt was not initially much emulated,
but following the intervention of the Mayor, a series of '
were organized which eventually raised enough money to start a small
Radium Institute, initially housed in the
Manchester Royal Infirmary.
In 1921 it moved to new premises in Nelson Street donated by Sir
Edward and Lady Holt, and became the
Manchester and District Radium
Institute. By contrast with the dispersed and competitive provision
of London radiotherapy,
Manchester became the first provider of a
centralised radiotherapy service, which would have long-lasting
effects on the patterns of British cancer care.
The Christie at Withington
In 1932 the Institute, renamed as the Holt
Radium Institute, and the
Christie Hospital moved to a new joint site in
Withington and began to
be jointly managed although a formal merger did not occur until
Ralston Paterson was appointed as Director of the
Radium Institute in
1931, and went on to build a world recognised centre for the treatment
of cancer by radiation. Among the team was his wife Edith Paterson,
who started research work at the Christie in 1938, initially unpaid,
and who became a world-renowned pioneer in biological dosimetry,
childhood cancers and anti-cancer drug treatment methods.[citation
needed] After Ralston Paterson's retirement in 1963, Professor Eric
Craig Easson, CBE, was appointed Director of the Christie Hospital. He
became world famous for his contribution to the curability of
Hodgkin's disease and to cancer education. He was awarded a personal
Professorial Chair at the University of Manchester, and was President
of the Royal College of Radiologists (1975–1977). He was the
government adviser on cancer for many years, and was a prime mover in
the Union Internationale Contre
Cancer in Geneva, as well as the WHO
cancer group. During Professor Easson's tenure as Director, many
doctors from throughout the world visited the Christie Hospital to
absorb its ethos, but particularly to learn its techniques.
Early impetuses to research came from new local diseases of
industrialisation such as mule spinners' cancer and chimney sweep's
cancer, and the search for links to machine oils and airborne soot.
Subsequent therapeutic milestones have included:
1932 - development of the
Manchester Method, the first international
standard for radium treatment
1944 - world's first clinical trial of diethylstilbestrol
(Stilboestrol) for breast cancer
1970 - world's first clinical use of tamoxifen (Nolvadex) for breast
1986 - world's first use of cultured bone marrow for leukaemia
1991 - world's first single harvest blood stem-cell transplant
Cancer Research UK
Manchester Institute (former Paterson Institute for
Professor Laszlo Lajtha was appointed director of research in 1962.
New research laboratories, provided by the Women's Trust Fund and
named after the Patersons, were opened in 1966. The Women's Trust Fund
was a local charity, chaired by Lady Margaret Holt, daughter-in-law of
Sir Edward Holt, who left her entire estate of over £8 million to the
Christie when she died in 1997. Core funding for the laboratories
was secured from the Medical Research Council and the
Campaign (CRC). The CRC also located the CRC Department of Medical
Oncology, led by Professor Derek Crowther, at the Paterson.
Lajtha was succeeded as Director in 1983 by Professor David Harnden.
Professor T. Michael Dexter served in the post for a short time before
the appointment of Professor Nic Jones as Director in March 1999. 
Professor Jones stepped down in 2011 and Professor Richard Marais was
appointed as the new Director in 2012. "
Cancer Research UK
Manchester Institute History". Retrieved 2017-03-31.
The Paterson Institute for
Cancer Research changed its name to the
Cancer Research UK
Manchester Institute on 1 October 2013.
The Christie registers around 12,500 new patients and treats about
40,000 patients every year. It is the lead cancer centre for the
Manchester and Cheshire
Cancer Network, covering a population
of 3.2 million, and runs clinics at 16 other general hospitals.
Around 15% of patients are referred from outside Greater Manchester
and Cheshire, and there is also a private patients unit. Patients are
referred from district general hospitals, having already had their
The Christie is the largest cancer treatment centre of its kind in
Europe and an international leader in research and development. As of
2010 the Christie is home to the largest clinical trials unit of its
kind in Europe.
The Christie annually delivers over 30,000 chemotherapy treatments and
undertakes around 3,700 operations every year. It has one of the eight
dedicated teenage cancer units in the United Kingdom. It has 257
inpatient beds with an average length of stay of seven days.
The hospital has one of the largest clinical trials units in the
United Kingdom for phase I/II cancer trials, with around 1,200
patients going on new trials, with plans to double over the next few
years to be one of largest clinical trials units in the world.
It is a partner in the
Cancer Research Centre and home to
the North West
Cancer Information Service, the cancer registry for the
whole of the North West region, and the Wolfson Molecular Imaging
HCA Healthcare has run a specialist private cancer unit in partnership
with the trust since 2010. 
The Christie became a
NHS Foundation Trust on 1 April 2007. It has a
total annual turnover of around £143 million. Eight percent of its
income is from private patients. Around 2,000 staff and over 300
volunteers work at the Christie.
The first Chair of the Trust was Jim Martin. He was replaced in May
2011 by Lord Keith Bradley 
Caroline Shaw, the chief executive of the trust, was suspended from
her duties on 19 December 2013 while investigations were conducted as
part of a disciplinary process. It was alleged that she had made an
improper claim for the payment of expenses for a retreat in Ibiza
organised by the Young Presidents' Organization, of which she had
become a member with the Trust’s agreement. In February 2014
Lord Bradley announced that he would resign from the board as a
consequences of disagreements about the way in which the suspension of
the Chief Executive was being handled. Sir Hugh Taylor was
appointed as interim Chair of the Trust. Shaw resigned in October
2014, having been suspended on full pay for 11 months- amounting to
£170,000 and left with another six months salary - just under
Dr Kim Holt, chair of the patient safety campaign group Patients
First, demanded an independent investigation into claims of bullying,
intimidation and dismissal of whistleblowers at the Trust in March
2014. A report was conducted by
Monitor (NHS) and the CQC which
concluded there was no evidence of serious failings of governance or
widespread cultural issues at the trust.
It was named by the
Health Service Journal
Health Service Journal as one of the top hundred
NHS trusts to work for in 2015. At that time it had 2,313 full-time
equivalent staff and a sickness absence rate of 3.41%. 92% of staff
recommend it as a place for treatment and 73% recommended it as a
place to work. The
Care Quality Commission
Care Quality Commission rated it as outstanding
On Wednesday 26 April 2017 at 10:36am, the fire service was called to
a building fire within the
Cancer Research UK
Manchester Institute at
Christie Hospital, it is believed that a blaze had broke out within
the roof, where maintenance had been done on the roof a week before
the blaze. The blaze involved five fire fighters, and an aerial
At 11:52am, the fire brigade had been praised by cancer experts for
saving 25 years of vital research from the blaze. 
Healthcare in Greater Manchester
List of hospitals in England
List of NHS trusts
Cancer in the United Kingdom
^ "Christie, Richard Copley (DNB01)". Dictionary of National Biography
(1901). 1901. Retrieved 2012-10-30.
Manchester Medical Collection: Hospitals and related institutions
Manchester area". Archived from the original on 22 December
2012. Retrieved 20 December 2007.
^ a b "Press Release - 13th May 2004". Archived from the original on
27 May 2007. Retrieved 20 December 2007.
^ a b "History of the Hospital". Archived from the original on 28
September 2007. Retrieved 6 December 2007.
^ British Medical Association (ed.) (1929) The Book of
Salford: for the 97th annual meeting. Manchester: George Falkner &
^ a b c Fox BW (1998). "The history of radium in medicine in
Manchester". Clin Oncol (R Coll Radiol). 10 (2): 115–24.
^ Ronald W. Raven. (1990). The Theory and Practice of Oncology.
Informa Healthcare. ISBN 1-85070-179-2.
^ a b Pickstone JV (2007). "Contested cumulations: configurations of
cancer treatments through the 20th century". Bull Hist Med. 81 (1):
164–96. doi:10.1353/bhm.2007.0011. PMC 2635842 .
^ a b "Paterson Institute for
Cancer Research - History of the
Institute". Archived from the original on 2007-08-13. Retrieved
^ Cite error: The named reference
Cancer Research UK Manchester
Institute History was invoked but never defined (see the help page).
^ a b c d "About the Christie". Archived from the original on 1 July
2007. Retrieved 6 December 2007.
^ "NHS expands private care to help fill £20bn funding gap".
Financial Times. 2 March 2016. Retrieved 26 January 2017.
^ Keith, Bradley. "Christie appoints new chairman". Archived from the
original on 29 October 2013. Retrieved 27 October 2013.
^ "The Christie hospital chief executive Caroline Shaw suspended".
Manchester Evening News. 19 December 2013. Retrieved 20 December
^ "Christie hospital chairman Lord Bradley to resign". Manchester
Evening News. 28 February 2014. Retrieved 10 March 2014.
^ "Boss of The Christie resigns after investigation into Ibiza trip".
Manchester Evening News. 10 October 2014. Retrieved 10 October
^ "Call for investigation into 'bullying' at cancer trust". Health
Service JOurnal. 3 March 2014. Retrieved 14 March 2014.
^ "Health watchdog says The Christie needs to develop 'open culture'
for staff to raise concerns".
Manchester Evening News. 27 November
2014. Retrieved 23 December 2014.
^ "HSJ reveals the best places to work in 2015". Health Service
Journal. 7 July 2015. Retrieved 23 September 2015.
Cancer hospital The Christie rated as 'outstanding'". BBC News. 18
November 2016. Retrieved 18 January 2017.
^ "Fire breaks out at
Manchester Christie hospital building". The
Telegraph. 26 April 2017. Retrieved 26 April 2017.
^ "Fire at Christie hospital cancer research labs". ITV News. 26 April
2017. Retrieved 26 April 2017.
NHS Foundation Trust homepage
About the Hospital
History of the Hospital
The Paterson Institute for
The Wolfson Molecular Imaging Centre
Coordinates: 53°25′47″N 2°13′43″W / 53.42972°N