Chloride channel blocker
   HOME

TheInfoList



OR:

A chloride channel blocker is a type of
drug A drug is any chemical substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support. Consumption of drugs can be via insuffla ...
which inhibits the transmission of
ion An ion () is an atom or molecule with a net electrical charge. The charge of an electron is considered to be negative by convention and this charge is equal and opposite to the charge of a proton, which is considered to be positive by conven ...
s (Cl) through
chloride channel Chloride channels are a superfamily of poorly understood ion channels specific for chloride. These channels may conduct many different ions, but are named for chloride because its concentration ''in vivo'' is much higher than other anions. Severa ...
s.
Niflumic acid Niflumic acid is a drug used for joint and muscular pain. It is categorized as an inhibitor of cyclooxygenase-2. In experimental biology, it has been employed to inhibit chloride channels. It has also been reported to act on GABA-A and NMDA chann ...
is a chloride channel blocker that has been used in experimental
scientific research The scientific method is an empirical method for acquiring knowledge that has characterized the development of science since at least the 17th century (with notable practitioners in previous centuries; see the article history of scientific m ...
. Another example is anthracene-9-carboxylic acid, a potent blocker of the
CLCN1 The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regul ...
-type chloride channel found in skeletal muscle, which is used to study animal models of
myotonia congenita Myotonia congenita is a congenital neuromuscular channelopathy that affects skeletal muscles (muscles used for movement). It is a genetic disorder. The hallmark of the disease is the failure of initiated contraction to terminate, often referred to ...
.


See also

*
Chloride channel opener A chloride channel opener is a type of drug which facilitates ion transmission through chloride channels. An example is 1,10-phenanthroline, which activates Cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels. GABA-A rec ...


References


Further reading

* * * * * * Drugs Ion channel blockers {{pharmacology-stub