Cullin-7 is a RING-E3 ligase
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''CUL7''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Clinical significance
It is associated with
3-M syndrome.
Interactions
CUL7 has been shown to
interact with
RBX1
RING-box protein 1 is a protein that in humans is encoded by the ''RBX1'' gene.
Function
This gene encodes an evolutionarily conserved protein that interacts with cullins. The protein plays a unique role in the ubiquitination reaction by heter ...
.
References
Further reading
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External links
GeneReviews/NIH/NCBI/UW entry on 3-M syndrome OMIM entries entry on 3-M syndrome*
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