CGP 52608 is a selective
ligand
In coordination chemistry, a ligand is an ion or molecule ( functional group) that binds to a central metal atom to form a coordination complex. The bonding with the metal generally involves formal donation of one or more of the ligand's elec ...
of the
RAR-related orphan receptor alpha
RAR-related orphan receptor alpha (RORĪ±), also known as NR1F1 (nuclear receptor subfamily 1, group F, member 1) is a nuclear receptor that in humans is encoded by the ''RORA'' gene. RORĪ± participates in the transcriptional regulation of some g ...
.
It has been used as a biochemical tool to investigate
nuclear and
membrane
A membrane is a selective barrier; it allows some things to pass through but stops others. Such things may be molecules, ions, or other small particles. Membranes can be generally classified into synthetic membranes and biological membranes. ...
signaling of
melatonin.
CGP 52608 has also been reported to possess
antiarthritic activity.
The pharmaceutical company Novartis brought it to
clinical trials for
rheumatoid arthritis
Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly, the wrist and hands are invol ...
, but
development
Development or developing may refer to:
Arts
*Development hell, when a project is stuck in development
*Filmmaking, development phase, including finance and budgeting
*Development (music), the process thematic material is reshaped
* Photograph ...
was discontinued in 2006.
CGP 52608 contains a
thiazolinidinedione group.
References
External links
* {{MeshName, CGP+52608
Thioureas
Thiazolidines
Allyl compounds
Lactams