CGP-35348 is a compound used in scientific research which acts as an
antagonist at
GABAB receptors
Receptor may refer to:
*Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse
*Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a n ...
.
CGP-35348 was ineffective up to 100 μM to antagonize the inhibitory release of GABA elicited by baclofen, doing it selective as
GABAB heteroreceptor antagonist.
Moreover, CGP-35348 was about threefold less potent to antagonize
gamma-hydroxybutyrate
''gamma''-Hydroxybutyric acid (or γ-hydroxybutyric acid (GHB), also known as 4-hydroxybutanoic acid) is a naturally occurring neurotransmitter and a depressant drug. It is a precursor to GABA, glutamate, and glycine in certain brain areas. ...
(GHB) and
gamma-butyrolactone (GBL) than
baclofen
Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity such as from a spinal cord injury or multiple sclerosis. It may also be used for hiccups and muscle spasms near the end of life. It is ta ...
and
SKF-97,541.
References
GABAB receptor antagonists
Phosphinic acids
{{nervous-system-drug-stub