Cadherin EGF LAG seven-pass G-type receptor 2 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''CELSR2''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
The protein encoded by this gene is a member of the
flamingo subfamily, part of the
cadherin superfamily. The flamingo subfamily consists of nonclassic-type
cadherins; a subpopulation that does not interact with
catenin
Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as α-catenin and β-catenin. α-Catenin can bind to β-catenin and can also bind ...
s. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as
homophilic binding regions and the EGF-like domains involved in
cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.
See also
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Flamingo (protein)
References
Further reading
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External links
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Adhesion G protein-coupled receptors
G protein-coupled receptors
{{transmembranereceptor-stub