CD8+ cell noncytotoxic anti-HIV response appears to be an anti-
HIV innate immune response
The innate, or nonspecific, immune system is one of the two main immunity strategies (the other being the adaptive immune system) in vertebrates. The innate immune system is an older evolutionary defense strategy, relatively speaking, and is the ...
because it can be observed in vitro with CD8+ cells from unexposed and uninfected healthy individuals.
The presence of a CD8+ cell noncytotoxic anti-HIV response (CNAR) was first reported in 1986 by researchers in the laboratory of Dr. Jay Levy at the University of California San Francisco (UCSF).
It was recognized that CD8+ cells from HIV-infected individuals can suppress HIV replication without directly killing the infected cells.
CNAR appears to be mediated by a CD8+ cell anti-HIV factor (CAF) that has not yet been identified. Other soluble factors can act against HIV including the β-chemokines.
References
HIV/AIDS
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