CD151

CD151 molecule (Raph blood group), also known as CD151 (Cluster of Differentiation 151), is a human gene.

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. Abnormalities in CD151 have been implicated in a form of epidermolysis bullosa.

Interactions

CD151 has been shown to Protein-protein interaction, interact with CD46.

See also

* Cluster of differentiation
* Tetraspanin

References

Further reading

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External links

Raph blood group system
in the BGMUT blood group antigen gene mutation database
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Clusters of differentiation

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Blood antigen systems
Transfusion medicine