The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a
G protein-coupled receptor
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related p ...
protein involved in the
complement system
The complement system, also known as complement cascade, is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and ...
.
The receptor binds to complement component
C3a, although there is limited evidence that this receptor also binds
C4a
Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen (HLA) system. It serves a number of critical functions in immunity, tolerance, and autoimmunity with ...
in lesser mammals this has yet to be proven true in humans.
C3a receptor modulates immunity, arthritis, diet-induced obesity and cancers
Agonists and antagonists
Potent and selective
agonists
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the agon ...
and
antagonists for C3aR have been discovered.
References
Further reading
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External links
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G protein-coupled receptors
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