Butanilicaine
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Butanilicaine is a
local anesthetic A local anesthetic (LA) is a medication that causes absence of pain sensation. In the context of surgery, a local anesthetic creates an absence of pain in a specific location of the body without a loss of consciousness, as opposed to a general a ...
. It is also known by the name Hostacaine.


Synthesis

The amide formation between 2-Chloro-6-Methylaniline 7-63-8(1) and Chloroacetyl chloride (2) gives 2-Chloro-n-(2-chloro-6-methylphenyl)acetamide 307-67-1(3). Alkylation with
N-Butylamine ''n''-Butylamine is an organic compound (specifically, an amine) with the formula CH3(CH2)3NH2. This colourless liquid is one of the four isomeric amines of butane, the others being ''sec''-butylamine, ''tert''-butylamine, and isobutylamine. It ...
(4) completed the synthesis of ''Butanilicaine'' (5).


References

Local anesthetics Acetanilides Chloroarenes {{nervous-system-drug-stub