Buphedrone, also known as α-methylamino-butyrophenone (MABP), is a stimulant of the phenethylamine and cathinone

chemical class Chemical classification systems attempt to classify elements or compounds according to certain chemical functional or structural properties. Whereas the structural properties are largely intrinsic, functional properties and the derived classificat ...

es that was first synthesized in 1928. It is legal in most countries as a research chemical, as long as it is not intended for human consumption.

Chemistry

Buphedrone is a beta-ketone and is related to the naturally occurring compounds, cathinone and cathine. It is also related to methamphetamine, differing by the β- ketone substituent (at the beta carbon) and an ethyl group replacing the methyl group at the carbon alpha to the

amine In chemistry, amines (, ) are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (), wherein one or more hydrogen Hydrogen is the chemical element wi ...

. One other name for buphedrone is phenylacetoethyl-methylamine. Buphedrone as free base is very unstable; it is prone to dimerization like other α-amino ketones. Because of this, it is sold as various salts, with a

hydrochloride In chemistry, a hydrochloride is an acid salt resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base (e.g. an amine). An alternative name is chlorhydrate, which comes from French. An archaic alternative n ...

being most common.

Effects

Buphedrone increases spontaneous rodent locomotor activity, potentiates the release of dopamine from dopaminergic nerve terminals in the

brain A brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It is located in the head, usually close to the sensory organs for senses such as vision. It is the most complex organ in a ve ...

, and causes

appetite suppression An anorectic or anorexic is a drug which reduces appetite, resulting in lower food consumption, leading to weight loss. By contrast, an appetite stimulant is referred to as orexigenic. The term is (from the Greek ''ἀν-'' (an-) = "without" and ...

. It also causes a possibly dangerous effect of decreasing subjective feeling of thirst. The effects of buphedrone have also been compared to methamphetamine, with more euphoria and less physical stimulation. Most commonly reported effects include: * Elevated mood, euphoria * Increased alertness * Dilated

pupil The pupil is a black hole located in the center of the Iris (anatomy), iris of the Human eye, eye that allows light to strike the retina.Cassin, B. and Solomon, S. (1990) ''Dictionary of Eye Terminology''. Gainesville, Florida: Triad Publishing ...

s (rare) * Slurred speech (rare) * Increased heart rate * Talkativeness * Increased empathy and sense of communication * Increased sex drive * Temporary erectile dysfunction in men * Restlessness * Insomnia * Increased motivation Depending on the route of administration, the duration varies from approximately 2.5 (IV) to 6 hours (orally) and may be followed by unpleasant symptoms associated with withdrawal, which may include: * Dysphoria * Tiredness * Sweating * Loss of concentration

Legal status

As of October 2015 buphedrone is a controlled substance in China. Buphedrone is an

Anlage II Anlage may refer to: * Allele, a specific version of a gene, as used by Gregor Mendel * Anlage Süd ''Anlage Süd'' (English: ''Installation South'') was a pair of railway headquarters built for Adolf Hitler in the Nazi-occupied part of southe ...

controlled drug in Germany.

References

{{Phenethylamines Cathinones Designer drugs Norepinephrine-dopamine releasing agents

Chemistry

Effects

Legal status

See also

References