Sir Bruce Anthony John Ponder
FMedSci FRS (born 25 April 1944) is an
English geneticist and cancer researcher. He is Emeritus Professor of
Oncology at the
University of Cambridge
University of Cambridge and former director of the
Cancer Research UK
Cancer Research UK Cambridge Institute.
4 Awards and honours
Ponder was educated at
Charterhouse School and Jesus College,
Cambridge. He carried out his PhD studies with
Lionel Crawford in
London working on chromatin organisation and DNA sequence specificity
using polyoma virus.
Ponder became interested in cancer genetics in the 1970s, when he saw
the potential to use new methods of linkage analysis (using
restriction fragment length polymorphisms) to identify genes that
predispose to cancer. His team pinpointed the RET gene as the cause of
Multiple endocrine neoplasia type 2. During the 1990s, Ponder
co-founded and chaired the International Breast Cancer Linkage
Consortium, which led to the identification of breast cancer
BRCA1 and BRCA2.
BRCA2 specifically was
identified by a team including Ponder and led by Mike
In 1996, Ponder became Cancer Research Campaign (now Cancer Research
UK) Professor of
Oncology in Cambridge (in 2007 the chair was
re-endowed as the
Li Ka Shing
Li Ka Shing Professor of Oncology). He served as
co-director of the
Strangeways Research Laboratory
Strangeways Research Laboratory for Genetic
Epidemiology and co-director of the Hutchison/MRC Research Centre.
Ponder was the inaugural Director of the CRUK Cambridge Research
Institute (now called the CRUK Cambridge Institute) when it opened in
2007. In this role he put an emphasis on building infrastructure
across the research pathway, from basic science through translational
research, ensuring that research has clinical impact. He was director
of the Cambridge Cancer Centre, a collaboration between the Institute,
University of Cambridge
University of Cambridge and Addenbrooke's Hospital, guiding the
centre to OECI Comprehensive Cancer Centre status in 2013.
Awards and honours
In 1997 Ponder delivered the
Croonian Lecture to the Royal College of
Physicians on the subject of the RET gene. He was elected a Fellow
Royal Society in 2001, he was knighted for Services to
Medicine in the
2008 New Year Honours list, and was awarded the
Cancer Research UK
Cancer Research UK Lifetime Achievement Prize. His nomination
Royal Society reads:
Bruce Ponder is distinguished for his contributions to human cancer
genetics and is a leader in the international collaborations which
have led to the identification of genes predisposing for breast and
ovarian cancer. His fundamental work on the intestine has underpinned
subsequent studies of tumours in the intestinal epithelium.
^ a b PONDER, Sir Bruce (Anthony John). ukwhoswho.com. Who's Who. 2015
Oxford University Press
Oxford University Press ed.). A & C Black, an imprint of
Bloomsbury Publishing plc. (subscription required)
^ "Professor Sir
Bruce Ponder FRS FMedSci". London: Academy of Medical
Sciences. Archived from the original on 2015-06-03.
^ Balmain, A; Gray, J; Ponder, B (2003). "The genetics and genomics of
cancer". Nature Genetics. 33 Suppl (3s): 238–44. doi:10.1038/ng1107.
^ Ponder, B. A.; Crew, F; Crawford, L. V. (1978). "Comparison of
nuclease digestion of polyoma virus nucleoprotein complex and mouse
chromatin". Journal of Virology. 25 (1): 175–86. PMC 353914 .
^ Mole, SE; Mulligan, LM; Healey, CS; Ponder, BA; Tunnacliffe, A
(March 1993). "Localisation of the gene for multiple endocrine
neoplasia type 2A to a 480 kb region in chromosome band 10q11.2". Hum
Mol Genet. 2 (3): 247–52. doi:10.1093/hmg/2.3.247.
^ Wooster, R.; Bignell, G.; Lancaster, J.; Swift, S.; Seal, S.;
Mangion, J.; Collins, N.; Gregory, S.; Gumbs, C.; Micklem, G.;
Barfoot, R.; Hamoudi, R.; Patel, S.; Rices, C.; Biggs, P.; Hashim, Y.;
Smith, A.; Connor, F.; Arason, A.; Gudmundsson, J.; Ficenec, D.;
Kelsell, D.; Tonin, P.; Timothy Bishop, D.; Spurr, N. K.; Ponder, B.
A. J.; Eeles, R.; Peto, J.; Devilee, P.; Cornelisse, C. (1995).
"Identification of the breast cancer susceptibility gene BRCA2".
Nature. 378 (6559): 789–792. doi:10.1038/378789a0.
^ Antoniou, A. C.; Pharoah, P. D.; McMullan, G; Day, N. E.; Stratton,
M. R.; Peto, J; Ponder, B. J.; Easton, D. F. (2002). "A comprehensive
model for familial breast cancer incorporating BRCA1,
BRCA2 and other
genes". British Journal of Cancer. 86 (1): 76–83.
doi:10.1038/sj.bjc.6600008. PMC 2746531 .
^ Stratton, J. F.; Buckley, C. H.; Lowe, D; Ponder, B. A. (1999).
"Comparison of prophylactic oophorectomy specimens from carriers and
noncarriers of a
BRCA2 gene mutation. United Kingdom
Coordinating Committee on Cancer Research (UKCCCR) Familial Ovarian
Cancer Study Group". Journal of the National Cancer Institute. 91 (7):
626–8. doi:10.1093/jnci/91.7.626. PMID 10203282.
^ Patel, K. J.; Yu, V. P.; Lee, H; Corcoran, A; Thistlethwaite, F. C.;
Evans, M. J.; Colledge, W. H.; Friedman, L. S.; Ponder, B. A.;
Venkitaraman, A. R. (1998). "Involvement of Brca2 in DNA repair".
Molecular Cell. 1 (3): 347–57. doi:10.1016/s1097-2765(00)80035-0.
^ Polly Curtis. "Interview:
Bruce Ponder Society". The Guardian.
^ "Addenbrooke's first general hospital in Europe to get stamp of
approval for cancer care and research Cambridge University
Hospitals". Cuh.org.uk. 12 September 2013. Retrieved 2016-02-19.
^ "Croonian Lectures (Sadleir Trust)" (PDF). Royal College of
Physicians. Archived from the original (PDF) on 2015-02-11. Retrieved
^ "Fellows of the Royal Society". Royal Society. Retrieved
^ "Professor Sir
Bruce Ponder FRS, Department Head and Director of the
Cambridge Cancer Centre, University of Cambridge".
research-europe.com. Archived from the original on 2015-02-11.
^ "Research Prizes". Cancer Research UK. Retrieved 2016-02-19.
^ "EC/2001/28: Ponder, Bruce Anthony John". London: The Royal Society.
Archived from the original on 2015-04-11.
Fellows of the
Royal Society elected in 2001
Robert J. Birgeneau
J. Richard Bond
James F. Crow
Anthony G. Evans
George M. Sheldrick
Mandyam Veerambudi Srinivasan
W. G. Unruh