Bromoderma is a skin condition characterized by an eruption of
papules and
pustules on the skin.
It is caused by hypersensitivity to
bromides, such as those found in certain drugs. There is at least one reported case of bromoderma caused by excessive consumption of a
soft drink
A soft drink (see § Terminology for other names) is a drink that usually contains water (often carbonated), a sweetener, and a natural and/or artificial flavoring. The sweetener may be a sugar, high-fructose corn syrup, fruit juice, a su ...
(
Ruby Red Squirt) containing
brominated vegetable oil
Brominated vegetable oil (BVO) is a complex mixture of plant-derived triglycerides that have been reacted to contain atoms of the element bromine bonded to the molecules. Brominated vegetable oil is used primarily to help emulsify citrus-flavored ...
.
Signs and symptoms
The disease's symptoms can range from a mild
acneiform rash with
papules and
pustules
A skin condition, also known as cutaneous condition, is any medical condition that affects the integumentary system—the organ system that encloses the body and includes skin, nails, and related muscle and glands. The major function of this sy ...
to more severe conditions like
panniculitis, ulcers, and vegetative
nodules
Nodule may refer to:
*Nodule (geology), a small rock or mineral cluster
*Manganese nodule, a metallic concretion found on the seafloor
*Nodule (medicine), a small aggregation of cells
*Root nodule
Root nodules are found on the roots of plants, p ...
, also referred to as tuberous or vegetating bromoderma. Lesions usually affect the lower limbs, scalp, and face.
Causes
One could characterize bromoderma as a kind of delayed
hypersensitivity reaction
Hypersensitivity (also called hypersensitivity reaction or intolerance) refers to undesirable reactions produced by the normal immune system, including allergies and autoimmunity. They are usually referred to as an over-reaction of the immune s ...
, even though its pathogenesis is still unknown.
Lesions can develop as soon as eight days after the medicine is first administered, but they typically do so after a prolonged period of use. High sebaceous gland concentrations on the skin are typically the site of lesions.
Diagnosis
Skin lesions, a patient's history of using
bromide, and the healing of lesions following drug withdrawal can all be used to make a diagnosis.
See also
*
Skin lesion
*
List of cutaneous conditions
Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the body and composed of skin, hair, nails, and related muscle and glands. The major function of this system is as a barrier against t ...
References
Further reading
*
External links
{{Disorders of skin appendages
Drug eruptions
Bromine