The Eli and Edythe L.
Broad Institute of MIT and Harvard (/ˈbroʊd/),
often referred to as the Broad Institute, is a biomedical and genomic
research center located in Cambridge, Massachusetts, United States.
The institute is independently governed and supported as a 501(c)(3)
nonprofit research organization under the name Broad Institute
Inc., and is partners with
Massachusetts Institute of
Technology, Harvard University, and the five Harvard teaching
Broad Institute, 415 Main St.
2 Organizational structure
3 Core members
8 Further reading
9 External links
Broad Institute evolved from a decade of research collaborations
among MIT and Harvard scientists. One cornerstone was the Center
Genome Research of
Whitehead Institute at MIT. Founded in 1982,
the Whitehead became a major center for genomics and the Human Genome
Project. As early as 1995, scientists at the Whitehead started pilot
projects in genomic medicine, forming an unofficial collaborative
network among young scientists interested in genomic approaches to
cancer and human genetics. Another cornerstone was the Institute of
Chemistry and Cell Biology established by
Harvard Medical School
Harvard Medical School in
1998 to pursue chemical genetics as an academic discipline. Its
screening facility was one of the first high-throughput resources
opened in an academic setting. It facilitated small molecule screening
projects for more than 80 research groups worldwide.
To create a new organization that was open, collaborative,
cross-disciplinary and able to organize projects at any scale,
planning took place in 2002–2003 among philanthropists Eli and
Edythe Broad, MIT, the Whitehead Institute, Harvard and the
Harvard-affiliated hospitals (in particular, the Beth Israel Deaconess
Medical Center, Brigham and Women's Hospital, Children's Hospital
Dana-Farber Cancer Institute and the
The Broads made a founding gift of $100 million and the Broad
Institute was formally launched in May 2004. In November 2005, the
Broads announced an additional $100 million gift to the Institute.
On September 4, 2008, the Broads announced an endowment of $400
million to make the
Broad Institute a permanent establishment. In
November 2013, they invested an additional $100 million to fund a
second decade of research at the institute.
Broad Institute has 11 core faculty and 195 associate members
from Harvard, MIT, and the Harvard-affiliated hospitals.
Broad Institute is made up of three types of organizational units:
core member laboratories, research programs, and platforms. The
institute's scientific research programs include:
Program in Medical and Population Genetics
Genome Biology and Cell Circuits Program
Chemical Biology Program
Infectious Disease Program
Stanley Center for Psychiatric Research at Broad Institute
Sequencing and Analysis Program
The Broad Institute's platforms are teams of professional scientists
who focus on the discovery, development, and optimization of the
technological tools that Broad and other researchers use to conduct
research. The platforms include:
Metabolite Profiling Platform
Genetic Perturbation Platform
Therapeutics Projects Group
Broad Institute also supports the Data Visualization Initiative
led by the Institute creative director Bang Wong, which is aimed at
developing data visualizations to explore and communicate research
The faculty and staff of the
Broad Institute include physicians,
geneticists, and molecular, chemical, and computational biologists.
The faculty currently includes 11 Core Members, whose labs are
primarily located within the Broad Institute, and 195 Associate
Members, whose primary labs are located at one of the universities or
The Core Members of the
Broad Institute include:
Paul Blainey is an expert in microfluidic systems to study single
molecules and cells; one of the main aims of his lab is to make
single-cell analysis routine.
Todd Golub, a physician-researcher, is director of the cancer program.
He applies genomic tools to the classification and study of cancers.
Myriam Heiman combines genetics, biochemistry, and cell biology to
study the features that define different types of neurons and their
vulnerability to disease.
Deborah Hung is a chemical biologist and an infectious disease
physician who studies the interactions between pathogens and their
hosts, with the goal of discovering new antibiotic targets.
Steven Hyman is the director of the Stanley Center for Psychiatric
Eric Lander is the director of the Broad Institute. A geneticist,
molecular biologist and mathematician, Lander has been a driving force
in the development of genomics and a prominent leader of the Human
Aviv Regev is a computational biologist with interests in biological
networks, gene regulation and evolution.
Stuart Schreiber is director of the Chemical Biology program. He has
developed systematic ways to explore biology, especially disease
biology, using small molecules toward the development of therapeutic
Edward Scolnick is the former President of Merck Research
Laboratories, former Director and current Chief Scientist of the
Stanley Center for Psychiatric Research.
Feng Zhang is an assistant professor at MIT who developed optogenetics
and genome editing (CRISPR) technologies.
The Broad Institute's facilities at 320 Charles Street in Cambridge,
Massachusetts, house one of the largest genome sequencing centers in
the world. As
WICGR (Whitehead Institute/MIT Center for Genome
Research), this facility was the largest contributor of sequence
information to the Human
In February 2006, The
Broad Institute expanded to a new building at
415 Main Street, adjacent to the
Whitehead Institute for Biomedical
Research. This seven-story 231,000-square-foot (21,500 m2)
building contains office, research laboratory, retail and museum
space. In 2011, the institute announced plans to construct an
additional tower adjacent to the 415 Main Street site at 75 Ames
Street. On May 21, 2014, the Broad officially inaugurated a
375,000-square-foot research building at 75 Ames Street in
Cambridge’s Kendall Square. The new facility has 15 floors, 11
of which are occupied, and has LEED gold certification. As of July
2014, it has around 800 occupants.
Between 2009 and 2012, the operating revenue of the institute was
approximately $200 million, with 55% of that coming from federal
grants. The Broad Foundation (Eli and Edythe Broad) has provided
$700 million in funding to the
Broad Institute as of February
The Klarman Family Foundation provided a $32.5 million grant to Broad
to study cellular processes in 2012. In October 2013, Fundación
Carlos Slim (the
Carlos Slim Foundation) of Mexico announced a $74
million grant to
Broad Institute for the SIGMA2 consortium.
In July 2014, coinciding with the publication of a new study on the
genetics of schizophrenia, the
Broad Institute received a $650
million gift from the Stanley Family Foundation, one of the largest
private gifts ever for scientific research.
On October 10, 2017, it was reported that Deerfield Management Co. was
giving $50 million to the
Broad Institute of MIT and Harvard to
support biology research.
Since 2010, the
Broad Institute has been listed on the Boston Globe's
Top Places to Work. The 2014 report from Thomson Reuters' ScienceWatch
entitled "The World's Most Influential Scientific Minds" recognized
that 12 out of the 17 "hottest" researchers in science belonged to
genomics, and 4 out of the top 5 were affiliated with the Broad
Institute. Additionally, Stacey B. Gabriel of the Broad Institute
topped this entire list. Twenty-eight researchers from Broad Institute
have been recognized on ISI's Highly Cited, a database that recognizes
the top 250 researchers in multiple areas of science.
Eric S. Lander,
Stuart L. Schreiber and
Edward M. Scolnick are members
of the National Academy of Sciences and the Institute of Medicine.
David Altshuler is a member of the Institute of Medicine. Feng
Zhang received the 2014 Alan T. Waterman Award from the National
Science Foundation, its highest honor that annually recognizes an
outstanding researcher under the age of 35, for contributions to both
optogenetics and CRISPR technology.
In biochemistry, genetics, and molecular biology areas, the institute
was ranked #1 in the "Mapping Excellence" report, a survey that
assessed high-impact publications.
For its architecture, Broad's 415 Main Street building architects
Elkus Manfredi Architects
Elkus Manfredi Architects of Boston and AHSC McLellan Copenhagen of
San Francisco received high honors in the 2007 Laboratory of the Year
competition of the R&D Magazine.
^ "Nonprofit Report for BROAD INSTITUTE INC". GuideStar.org. Retrieved
6 July 2014.
^ "Broad Institute-MIT & Harvard". Manta Media Inc.
Broad Institute created: Links Harvard, M.I.T., and others in
interdisciplinary initiative in genomics and medicine". Harvard
Gazette. 2003-07-17. Retrieved 2007-12-25.
^ "A Brief History of the ICCB-Longwood Screening Facility". Harvard
Medical School. Archived from the original on 2007-12-19. Retrieved
^ "Broads' Dollars Doubled". Broad Institute. 2005-11-30.
^ "Philanthropists Eli and Edythe L. Broad make unprecedented gift to
Broad Institute of Harvard and MIT".
Broad Institute launches next decade with new $100M gift".
^ "Core Faculty Labs". Retrieved 2014-05-21.
^ "195 faculty members from Harvard, MIT and the Harvard teaching
hospitals appointed as Broad associate members". Broad Communications.
^ Broad Programs,
Broad Institute official website (retrieved October
^ Broad Platforms,
Broad Institute official site (retrieved October
^ "Data Visualization Initiative". Broad Institute. Retrieved 5 June
Broad Institute welcomes 135 associate members", Broad Institute
(November 4, 2011).
Broad Institute official website, Retrieved 10-30-2012.
^ "Steven E. Hyman, M.D.", Broad Institute. Retrieved October 30,
^ "Contact -
Broad Institute of MIT and Harvard".
^ Lipinski, Pearle. "Broad plans extension in Cambridge Center".
Retrieved 3 March 2011.
Broad Institute celebrates opening of new building". Retrieved 21
Broad Institute Annual Report 2012" (PDF). Broad Institute.
Retrieved 22 July 2014.
^ "PHILANTHROPY 50 - No. 15: Eli and Edythe Broad". The Chronicle of
Philanthropy. Retrieved 22 July 2014.
Broad Institute Receives $32.5 Million From Klarman Family
Foundation". Philanthropy News Digest. Foundation Center. Retrieved 22
Carlos Slim Foundation Awards $74 Million to Broad Institute
Genomics Center". Philanthropy News Digest. Foundation Center.
Retrieved 22 July 2014.
^ Weintraub, Karen. "
Schizophrenia has clear genetic ties, new study
finds". USA Today. Retrieved 22 July 2014.
^ "Spark for a Stagnant Search: A $650 Million Donation for
Psychiatric Research". New York Times. New York Times. Retrieved 22
^ Fidler, Ben. "Stanley Gives
Broad Institute $650M Gift For Psych
Research". Xconomy. Xconomy. Retrieved 22 July 2014.
^ Nickisch, Curt. "Inspired By Family Illness, Philanthropist Gives
$650 Million For Psychiatric Research". WBUR's Common Health. WBUR.
Retrieved 22 July 2014.
^ Rockoff, Jonathan D. (October 10, 2017). "Deerfield Management to
Fund Biology Research at Broad Institute". Wall Street Journal. New
York City, New York, United States. Retrieved October 10, 2017.
^ "THE WORLD'S MOST INFLUENTIAL SCIENTIFIC MINDS 2014" (PDF).
Retrieved 30 June 2014.
^ "ISI Highly Cited". highlycited.com/. Retrieved 30 June 2014.
^ "NAS Members".
National Academy of Sciences. Retrieved 30 June 2014.
^ "IOM Members". IOM Members. Institute of Medicine. Retrieved 30 June
2014. [permanent dead link]
National Science Foundation
National Science Foundation names
Feng Zhang its Alan T.
Waterman Awardee for 2014".
www.nsf.gov/news/news_summ.jsp?cntn_id=131048. NSF. Retrieved 30 June
^ "The World's Best (And Worst) Scientific Institutions Ranked By
Technology Review. Retrieved 6 July 2014.
^ "R&D Magazine Lab of the Year Winners".
Retrieved 30 June 2014.
commentary on the Broad Institute's website, receiving a 4-star
Kevin Ahern, Ph.D. (2009). "GEN Best of the Web". Genetic Engineering
& Biotechnology News. 29 (8): 66.
Wikimedia Commons has media related to Broad Institute.
Official website of the Broad Institute
Broad iBridge Page
Coordinates: 42°22′04″N 71°05′13″W / 42.36789°N
71.08703°W / 42.36789; -71.08703
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European Nucleotide Archive
European Nucleotide Archive and DNA Data
Bank of Japan
Secondary databases: UniProt, database of protein sequences grouping
TrEMBL and Protein Information Resource
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Ensembl and InterPro
Specialised genomic databases: BOLD, Saccharomyces
FlyBase, VectorBase, WormBase, PHI-base, Arabidopsis Information
Resource and Zebrafish Information Network
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