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Benorilate (
Acetyl salicoyl chloride 538-51-2(1) is reacted with paracetamol (2) to give benorilate (3).
Saponification of the ester led to Acetaminosalol (Phenetsal) 18-57-0
INN
Inns are generally establishments or buildings where travelers can seek lodging, and usually, food and drink. Inns are typically located in the country or along a highway; before the advent of motorized transportation they also provided accommo ...
), or benorylate, is an ester
In chemistry, an ester is a compound derived from an oxoacid (organic or inorganic) in which at least one hydroxyl group () is replaced by an alkoxy group (), as in the substitution reaction of a carboxylic acid and an alcohol. Glycerides ar ...
-linked codrug
A codrug or "mutual prodrug" consists of two synergistic drugs chemically linked together to a ''single molecule'', in order to improve the drug delivery properties of one or both drugs.
An effective codrug should be pharmacologically inactive ...
of aspirin
Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and/or inflammation, and as an antithrombotic. Specific inflammatory conditions which aspirin is used to treat inc ...
with paracetamol
Paracetamol, also known as acetaminophen, is a medication used to treat fever and mild to moderate pain. Common brand names include Tylenol and Panadol.
At a standard dose, paracetamol only slightly decreases body temperature; it is inferior ...
. It is used as an anti-inflammatory and antipyretic medication. In the treatment of childhood fever, it has been shown to be inferior to paracetamol and aspirin taken separately. In addition, because it is converted to aspirin, benorylate is not recommended in children due to concerns about Reye syndrome
Reye syndrome is a rapidly worsening brain disease. Symptoms of Reye syndrome may include vomiting, personality changes, confusion, seizures, and loss of consciousness. While liver toxicity typically occurs in the syndrome, jaundice usually do ...
.
Synthesis
Acetyl salicoyl chloride 538-51-2(1) is reacted with paracetamol (2) to give benorilate (3).
Saponification of the ester led to Acetaminosalol (Phenetsal) 18-57-0
References