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In epidemiology, the basic reproduction number, or basic reproductive number (sometimes called basic reproduction ratio or basic reproductive rate), denoted R_0 (pronounced ''R nought'' or ''R zero''), of an infection is the expected number of cases directly generated by one case in a population where all individuals are susceptible to infection. The definition assumes that no other individuals are infected or immunized (naturally or through vaccination). Some definitions, such as that of the Australian Department of Health, add the absence of "any deliberate intervention in disease transmission". The basic reproduction number is not the same as the effective reproduction number R (usually written R_t 't'' for time sometimes R_e), which is the number of cases generated in the current state of a population, which does not have to be the uninfected state. R_0 is a dimensionless number and not a rate, which would have units of time−1, or units of time like doubling time. R_0 is not a biological constant for a pathogen as it is also affected by other factors such as environmental conditions and the behaviour of the infected population. R_0 values are usually estimated from mathematical models, and the estimated values are dependent on the model used and values of other parameters. Thus values given in the literature only make sense in the given context and it is recommended not to use obsolete values or compare values based on different models. R_0 does not by itself give an estimate of how fast an infection spreads in the population. The most important uses of R_0 are determining if an emerging infectious disease can spread in a population and determining what proportion of the population should be immunized through vaccination to eradicate a disease. In commonly used infection models, when R_0 > 1 the infection will be able to start spreading in a population, but not if R_0 < 1. Generally, the larger the value of R_0, the harder it is to control the epidemic. For simple models, the proportion of the population that needs to be effectively immunized (meaning not susceptible to infection) to prevent sustained spread of the infection has to be larger than 1 - 1 / R_0. Conversely, the proportion of the population that remains susceptible to infection in the endemic equilibrium is 1 / R_0. The basic reproduction number is affected by several factors, including the duration of infectivity of affected people, the infectiousness of the microorganism, and the number of susceptible people in the population that the infected people contact.


History


The roots of the basic reproduction concept can be traced through the work of Ronald Ross, Alfred Lotka and others, but its first modern application in epidemiology was by George MacDonald in 1952, who constructed population models of the spread of malaria. In his work he called the quantity basic reproduction rate and denoted it by Z_0. Calling the quantity a rate can be misleading, insofar as "rate" can then be misinterpreted as a number per unit of time. "Number" or "ratio" is now preferred.


Definitions in specific cases





Contact rate and infectious period


Suppose that infectious individuals make an average of \beta infection-producing contacts per unit time, with a mean infectious period of \tau. Then the basic reproduction number is:R_0 = \beta\,\tauThis simple formula suggests different ways of reducing R_0 and ultimately infection propagation. It is possible to decrease the number of infection-producing contacts per unit time \beta by reducing the number of contacts per unit time (for example staying at home if the infection requires contact with others to propagate) or the proportion of contacts that produces infection (for example wearing some sort of protective equipment). Hence, it can also be written as :R_0 = \overline\, T\, \tau, where \overline is the rate of contact between susceptible and infected individuals and T is the transmissibility, i.e, the probability of infection given a contact. It is also possible to decrease the infectious period \tau by finding and then isolating, treating or eliminating (as is often the case with animals) infectious individuals as soon as possible.


With varying latent periods


Latent period is the transition time between contagion event and disease manifestation. In cases of diseases with varying latent periods, the basic reproduction number can be calculated as the sum of the reproduction numbers for each transition time into the disease. An example of this is tuberculosis (TB). Blower and coauthors calculated from a simple model of TB the following reproduction number:R_0 = R_0^ + R_0^In their model, it is assumed that the infected individuals can develop active TB by either direct progression (the disease develops immediately after infection) considered above as FAST tuberculosis or endogenous reactivation (the disease develops years after the infection) considered above as SLOW tuberculosis.


Heterogeneous populations


In populations that are not homogeneous, the definition of R_0 is more subtle. The definition must account for the fact that a typical infected individual may not be an average individual. As an extreme example, consider a population in which a small portion of the individuals mix fully with one another while the remaining individuals are all isolated. A disease may be able to spread in the fully mixed portion even though a randomly selected individual would lead to fewer than one secondary case. This is because the typical infected individual is in the fully mixed portion and thus is able to successfully cause infections. In general, if the individuals infected early in an epidemic are on average either more likely or less likely to transmit the infection than individuals infected late in the epidemic, then the computation of R_0 must account for this difference. An appropriate definition for R_0 in this case is "the expected number of secondary cases produced, in a completely susceptible population, produced by a typical infected individual". The basic reproduction number can be computed as a ratio of known rates over time: if an infectious individual contacts \beta other people per unit time, if all of those people are assumed to contract the disease, and if the disease has a mean infectious period of \dfrac, then the basic reproduction number is just R_0 = \dfrac. Some diseases have multiple possible latency periods, in which case the reproduction number for the disease overall is the sum of the reproduction number for each transition time into the disease. For example, Blower et al. model two forms of tuberculosis infection: in the fast case, the symptoms show up immediately after exposure; in the slow case, the symptoms develop years after the initial exposure (endogenous reactivation). The overall reproduction number is the sum of the two forms of contraction: R_0 = R_^ + R_0^.

Estimation methods

The basic reproduction number can be estimated through examining detailed transmission chains or through genomic sequencing. However, it is most frequently calculated using epidemiological models. During an epidemic, typically the number of diagnosed infections N(t) over time t is known. In the early stages of an epidemic, growth is exponential, with a logarithmic growth rateK := \frac.For exponential growth, N can be interpreted as the cumulative number of diagnoses (including individuals who have recovered) or the present number of infection cases; the logarithmic growth rate is the same for either definition. In order to estimate R_0, assumptions are necessary about the time delay between infection and diagnosis and the time between infection and starting to be infectious. In exponential growth, K is related to the doubling time T_d asK=\frac.


Simple model


If an individual, after getting infected, infects exactly R_0 new individuals only after exactly a time \tau (the serial interval) has passed, then the number of infectious individuals over time grows asn_E(t) = n_E(0)\, R_0^ = n_E(0)\,e^or\ln(n_E(t)) = \ln(n_E(0))+\ln(R_0)t/\tau.The underlying matching differential equation is\frac =n_E(t)\frac .or\frac =\frac .In this case, R_0 = e^ or K = \frac. For example, with \tau=5~\mathrm and K=0.183~\mathrm^, we would find R_0=2.5. If R_0 is time dependent\ln(n_E(t)) = \ln(n_E(0))+\frac\int\limits_^\ln(R_0(t))dtshowing that it may be important to keep \ln(R_0) below 0, time-averaged, to avoid exponential growth.


Latent infectious period, isolation after diagnosis


In this model, an individual infection has the following stages: # Exposed: an individual is infected, but has no symptoms and does not yet infect others. The average duration of the exposed state is \tau_E. # Latent infectious: an individual is infected, has no symptoms, but does infect others. The average duration of the latent infectious state is \tau_I. The individual infects R_0 other individuals during this period. # isolation after diagnosis: measures are taken to prevent further infections, for example by isolating the infected person. This is a SEIR model and R_0 may be written in the following formR_0 = 1 + K(\tau_E+\tau_I) + K^2\tau_E\tau_I.This estimation method has been applied to COVID-19 and SARS. It follows from the differential equation for the number of exposed individuals n_E and the number of latent infectious individuals n_I,\frac \begin n_E \\ n_I \end = \begin -1/\tau_E & R_0/\tau_I \\ 1/\tau_E & -1/\tau_I \end \begin n_E \\ n_I \end.The largest eigenvalue of the matrix is the logarithmic growth rate K, which can be solved for R_0. In the special case \tau_I = 0, this model results in R_0=1+K\tau_E, which is different from the simple model above (R_0=\exp(K\tau_E)). For example, with the same values \tau=5~\mathrm and K=0.183~\mathrm^, we would find R_0=1.9, rather than the true value of 2.5. The difference is due to a subtle difference in the underlying growth model; the matrix equation above assumes that newly infected patients are currently already contributing to infections, while in fact infections only occur due to the number infected at \tau_E ago. A more correct treatment would require the use of delay differential equations.

Effective reproduction number

In reality, varying proportions of the population are immune to any given disease at any given time. To account for this, the effective reproduction number R_e is used, usually written as R_t, or the average number of new infections caused by a single infected individual at time ''t'' in the partially susceptible population. It can be found by multiplying R_0 by the fraction ''S'' of the population that is susceptible. When the fraction of the population that is immune increases (i. e. the susceptible population ''S'' decreases) so much that R_e drops below 1, "herd immunity" has been achieved and the number of cases occurring in the population will gradually decrease to zero.

Limitations of ''R''0

Use of R_0 in the popular press has led to misunderstandings and distortions of its meaning. R_0 can be calculated from many different mathematical models. Each of these can give a different estimate of R_0, which needs to be interpreted in the context of that model. Therefore, the contagiousness of different infectious agents cannot be compared without recalculating R_0 with invariant assumptions. R_0 values for past outbreaks might not be valid for current outbreaks of the same disease. Generally speaking, R_0 can be used as a threshold, even if calculated with different methods: if R_0 < 1, the outbreak will die out, and if R_0 > 1, the outbreak will expand. In some cases, for some models, values of R_0 < 1 can still lead to self-perpetuating outbreaks. This is particularly problematic if there are intermediate vectors between hosts, such as malaria. Therefore, comparisons between values from the "Values of R_0 of well-known infectious diseases" table should be conducted with caution. Although R_0 cannot be modified through vaccination or other changes in population susceptibility, it can vary based on a number of biological, sociobehavioral, and environmental factors. It can also be modified by physical distancing and other public policy or social interventions, although some historical definitions exclude any deliberate intervention in reducing disease transmission, including nonpharmacological interventions. And indeed, whether nonpharmacological interventions are included in R_0 often depends on the paper, disease, and what if any intervention is being studied. This creates some confusion, because R_0 is not a constant; whereas most mathematical parameters with "nought" subscripts are constants. R depends on many factors, many of which need to be estimated. Each of these factors adds to uncertainty in estimates of R. Many of these factors are not important for informing public policy. Therefore, public policy may be better served by metrics similar to R, but which are more straightforward to estimate, such as doubling time or half-life (t1⁄2). Methods used to calculate R_0 include the survival function, rearranging the largest eigenvalue of the Jacobian matrix, the next-generation method, calculations from the intrinsic growth rate, existence of the endemic equilibrium, the number of susceptibles at the endemic equilibrium, the average age of infection and the final size equation. Few of these methods agree with one another, even when starting with the same system of differential equations. Even fewer actually calculate the average number of secondary infections. Since R_0 is rarely observed in the field and is usually calculated via a mathematical model, this severely limits its usefulness.

In popular culture

In the 2011 film ''Contagion'', a fictional medical disaster thriller, a blogger's calculations for R_0 are presented to reflect the progression of a fatal viral infection from case studies to a pandemic. The methods depicted were faulty.


See also


* Compartmental models in epidemiology * E-epidemiology * Epi Info software program * Epidemiological method * Epidemiological transition


Notes


*Compartmental models in epidemiology describe disease dynamics over time in a population of susceptible (S), infectious (I), and recovered (R) people using the SIR model. Note that in the SIR model, R(0) and R_0 are different quantities – the former describes the number of recovered at ''t'' = 0 whereas the latter describes the ratio between the frequency of contacts to the frequency of recovery. * According to Guangdong Provincial Center for Disease Control and Prevention, "The effective reproductive number (R or R is more commonly used to describe transmissibility, which is defined as the average number of secondary cases generated by per 'sic''infectious case." For example, by one preliminary estimate during the ongoing pandemic, the effective reproductive number for SARS-CoV-2 was found to be 2.9, whereas for SARS it was 1.77.


References





Further reading


* * * * {{DEFAULTSORT:Basic Reproduction Number Category:Articles containing video clips Category:Epidemiology Category:Epidemics Category:Pandemics