Indications
As other LABAs, bambuterol is used in the long-term management of persistent asthma. It should not be used as a rescue medication for short-term relief of asthma symptoms.Contraindications
Bambuterol is contraindicated in pregnancy and in people with seriously Liver failure, impaired liver function. It can be used by people with Renal failure, renal impairment, but dose adjustments are necessary.Adverse effects
The adverse effect profile of bambuterol is similar to that of salbutamol, and may include Fatigue (medical), fatigue, nausea, palpitations, headache, dizziness and tremor.Interactions
Concomitant administration of bambuterol with corticosteroids, diuretics, and xanthine derivatives (such as theophylline) increases the risk of hypokalemia (decreased levels of potassium in the blood).Sweetman (2009), pp. 1132–33. Bambuterol acts as a cholinesterase inhibitor, and can prolong the duration of action of suxamethonium (succinylcholine) and other drugs whose breakdown in the body depends on cholinesterase function. Butyrylcholinesterase activity returns to normal approximately two weeks after bambuterol is stopped. It can also enhance the effects of Neuromuscular-blocking drug#Non-depolarizing blocking agents, non-depolarizing Neuromuscular-blocking drug, neuromuscular blockers, such as vecuronium bromide.References
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