Balofloxacin (

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) is a fluoroquinolone

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. It is sold under the brand name Q-Roxin in

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, and under various names in India. It is not approved by the FDA for use in the United States.

Pharmacodynamics

Balofloxacin is a fluoroquinolone that has a broad spectrum in vitro activity against a wide range of Gram-positive and

Gram-negative Gram-negative bacteria are bacteria that do not retain the crystal violet stain used in the Gram staining method of bacterial differentiation. They are characterized by their cell envelopes, which are composed of a thin peptidoglycan cell wall ...

bacteria, with enhanced activity against Gram positive bacteria, including MRSA and Streptococcus pneumoniae. It functions by inhibiting the action of DNA-gyrase, preventing bacterial cells from reproducing or repairing themselves, resulting in cellular death.

Side Effects

Vomiting, headache, dizziness, stomach pain, nausea, diarrhea and decreased liver function are the most common side effects. In rare cases, Balofloxacin can lead to or worsen tendinitis, and muscular damage.

References

Fluoroquinolone antibiotics Phenol ethers Piperidines Cyclopropanes Carboxylic acids Aromatic ketones {{antibiotic-stub

Pharmacodynamics

Side Effects

See also

References