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B. acidiceler B. acidicola B. acidiproducens B. acidocaldarius B. acidoterrestris B. aeolius B. aerius B. aerophilus B. agaradhaerens B. agri B. aidingensis B. akibai B. alcalophilus B. algicola B. alginolyticus B. alkalidiazotrophicus B. alkalinitrilicus B. alkalisediminis B. alkalitelluris B. altitudinis B. alveayuensis B. alvei B. amyloliquefaciens

B. a. subsp. amyloliquefaciens B. a. subsp. plantarum

B. aminovorans[2] B. amylolyticus B. andreesenii B. aneurinilyticus B. anthracis B. aquimaris B. arenosi B. arseniciselenatis B. arsenicus B. aurantiacus B. arvi B. aryabhattai B. asahii B. atrophaeus B. axarquiensis B. azotofixans B. azotoformans B. badius B. barbaricus B. bataviensis B. beijingensis B. benzoevorans B. beringensis B. berkeleyi B. beveridgei B. bogoriensis B. boroniphilus B. borstelensis B. brevis Migula B. butanolivorans B. canaveralius B. carboniphilus B. cecembensis B. cellulosilyticus B. centrosporus B. cereus B. chagannorensis B. chitinolyticus B. chondroitinus B. choshinensis B. chungangensis B. cibi B. circulans B. clarkii B. clausii B. coagulans B. coahuilensis B. cohnii B. composti B. curdlanolyticus B. cycloheptanicus B. cytotoxicus B. daliensis B. decisifrondis B. decolorationis B. deserti B. dipsosauri B. drentensis B. edaphicus B. ehimensis B. eiseniae B. enclensis B. endophyticus B. endoradicis B. farraginis B. fastidiosus B. fengqiuensis B. firmus B. flexus B. foraminis B. fordii B. formosus B. fortis B. fumarioli B. funiculus B. fusiformis B. galactophilus B. galactosidilyticus B. galliciensis B. gelatini B. gibsonii B. ginsengi B. ginsengihumi B. ginsengisoli B. glucanolyticus B. gordonae B. gottheilii B. graminis B. halmapalus B. haloalkaliphilus B. halochares B. halodenitrificans B. halodurans B. halophilus B. halosaccharovorans B. hemicellulosilyticus B. hemicentroti B. herbersteinensis B. horikoshii B. horneckiae B. horti B. huizhouensis B. humi B. hwajinpoensis B. idriensis B. indicus B. infantis B. infernus B. insolitus B. invictae B. iranensis B. isabeliae B. isronensis B. jeotgali B. kaustophilus B. kobensis B. kochii B. kokeshiiformis B. koreensis B. korlensis B. kribbensis B. krulwichiae B. laevolacticus B. larvae B. laterosporus B. lautus B. lehensis B. lentimorbus B. lentus B. licheniformis B. ligniniphilus B. litoralis B. locisalis B. luciferensis B. luteolus B. luteus B. macauensis B. macerans B. macquariensis B. macyae B. malacitensis B. mannanilyticus B. marisflavi B. marismortui B. marmarensis B. massiliensis B. megaterium B. mesonae B. methanolicus B. methylotrophicus B. migulanus B. mojavensis B. mucilaginosus B. muralis B. murimartini B. mycoides B. naganoensis B. nanhaiensis B. nanhaiisediminis B. nealsonii B. neidei B. neizhouensis B. niabensis B. niacini B. novalis B. oceanisediminis B. odysseyi B. okhensis B. okuhidensis B. oleronius B. oryzaecorticis B. oshimensis B. pabuli B. pakistanensis B. pallidus B. pallidus B. panacisoli B. panaciterrae B. pantothenticus B. parabrevis B. paraflexus B. pasteurii B. patagoniensis B. peoriae B. persepolensis B. persicus B. pervagus B. plakortidis B. pocheonensis B. polygoni B. polymyxa B. popilliae B. pseudalcalophilus B. pseudofirmus B. pseudomycoides B. psychrodurans B. psychrophilus B. psychrosaccharolyticus B. psychrotolerans B. pulvifaciens B. pumilus B. purgationiresistens B. pycnus B. qingdaonensis B. qingshengii B. reuszeri B. rhizosphaerae B. rigui B. ruris B. safensis B. salarius B. salexigens B. saliphilus B. schlegelii B. sediminis B. selenatarsenatis B. selenitireducens B. seohaeanensis B. shacheensis B. shackletonii B. siamensis B. silvestris B. simplex B. siralis B. smithii B. soli B. solimangrovi B. solisalsi B. songklensis B. sonorensis B. sphaericus B. sporothermodurans B. stearothermophilus B. stratosphericus B. subterraneus B. subtilis

B. s. subsp. inaquosorum B. s. subsp. spizizenii B. s. subsp. subtilis

B. taeanensis B. tequilensis B. thermantarcticus B. thermoaerophilus B. thermoamylovorans B. thermocatenulatus B. thermocloacae B. thermocopriae B. thermodenitrificans B. thermoglucosidasius B. thermolactis B. thermoleovorans B. thermophilus B. thermoruber B. thermosphaericus B. thiaminolyticus B. thioparans B. thuringiensis
B. thuringiensis
B. tianshenii B. trypoxylicola B. tusciae B. validus B. vallismortis B. vedderi B. velezensis B. vietnamensis B. vireti B. vulcani B. wakoensis B. weihenstephanensis B. xiamenensis B. xiaoxiensis B. zhanjiangensis

Gram stain of a Bacillus
Bacillus
species

Bacillus
Bacillus
is a genus of gram-positive, rod-shaped bacteria and a member of the phylum Firmicutes. Bacillus
Bacillus
species can be obligate aerobes (oxygen reliant), or facultative anaerobes (having the ability to be aerobic or anaerobic). They will test positive for the enzyme catalase when there has been oxygen used or present.[3] Ubiquitous in nature, Bacillus
Bacillus
includes both free-living (nonparasitic) and parasitic pathogenic species. Under stressful environmental conditions, the bacteria can produce oval endospores that are not true 'spores', but to which the bacteria can reduce themselves and remain in a dormant state for very long periods. These characteristics originally defined the genus, but not all such species are closely related, and many have been moved to other genera of the Firmicutes.[4] Many species of Bacillus
Bacillus
can produce copious amounts of enzymes which are used in different industries. Some species can form intracellular inclusions of polyhydroxyalkanoates under certain adverse environmental conditions, as in a lack of elements such as phosphorus, nitrogen, or oxygen combined with an excessive supply of carbon sources. B. subtilis
B. subtilis
has proved a valuable model for research. Other species of Bacillus
Bacillus
are important pathogens, causing anthrax and food poisoning.

Contents

1 Industrial significance 2 Use as model organism 3 Ecological significance 4 Clinical significance 5 Cell wall 6 Phylogeny 7 See also 8 References 9 External links

Industrial significance[edit] Many Bacillus
Bacillus
species are able to secrete large quantities of enzymes. Bacillus amyloliquefaciens is the source of a natural antibiotic protein barnase (a ribonuclease), alpha amylase used in starch hydrolysis, the protease subtilisin used with detergents, and the BamH1
BamH1
restriction enzyme used in DNA research. A portion of the Bacillus thuringiensis
Bacillus thuringiensis
genome was incorporated into corn (and cotton) crops. The resulting GMOs are therefore resistant to some insect pests. Use as model organism[edit]

Colonies of the model species Bacillus subtilis
Bacillus subtilis
on an agar plate.

Bacillus subtilis
Bacillus subtilis
is one of the best understood prokaryotes, in terms of molecular and cellular biology. Its superb genetic amenability and relatively large size have provided the powerful tools required to investigate a bacterium from all possible aspects. Recent improvements in fluorescent microscopy techniques have provided novel insight into the dynamic structure of a single cell organism. Research on B. subtilis has been at the forefront of bacterial molecular biology and cytology, and the organism is a model for differentiation, gene/protein regulation, and cell cycle events in bacteria.[5] Ecological significance[edit] Bacillus
Bacillus
species are almost ubiquitous in nature, e.g. in soil, but also occur in extreme environments such as high pH (B. alcalophilus), high temperature (B. thermophilus), or high salt (B. halodurans). B. thuringiensis produces a toxin that can kill insects and thus has been used as insecticide.[6] B. siamensis has antimicrobial compounds that inhibit plant pathogens, such as the fungi Rhizoctonia solani
Rhizoctonia solani
and Botrytis cinerea, and they promote plant growth by volatile emissions.[7] Some species of Bacillus
Bacillus
are naturally competent for DNA uptake by transformation.[8] Clinical significance[edit] Two Bacillus
Bacillus
species are considered medically significant: B. anthracis, which causes anthrax, and B. cereus, which causes food poisoning similar to that caused by Staphylococcus.[9] A third species, B. thuringiensis, is an important insect pathogen, and is sometimes used to control insect pests. The type species is B. subtilis, an important model organism. It is also a notable food spoiler, causing ropiness in bread and related food. Some environmental and commercial strains of B. coagulans may play a role in food spoilage of highly acidic, tomato-based products. An easy way to isolate Bacillus
Bacillus
species is by placing nonsterile soil in a test tube with water, shaking, placing in melted mannitol salt agar, and incubating at room temperature for at least a day. Colonies are usually large, spreading, and irregularly shaped. Under the microscope, the Bacillus
Bacillus
cells appear as rods, and a substantial portion of the cells usually contain oval endospores at one end, making it bulge. Cell wall[edit] The cell wall of Bacillus
Bacillus
is a structure on the outside of the cell that forms the second barrier between the bacterium and the environment, and at the same time maintains the rod shape and withstands the pressure generated by the cell's turgor. The cell wall is composed of teichoic and teichuronic acids. B. subtilis
B. subtilis
is the first bacterium for which the role of an actin-like cytoskeleton in cell shape determination and peptidoglycan synthesis was identified, and for which the entire set of peptidoglycan-synthesizing enzymes was localised. The role of the cytoskeleton in shape generation and maintenance is important Phylogeny[edit] The genus Bacillus
Bacillus
was named in 1835 by Christian Gottfried Ehrenberg, to contain rod-shaped (bacillus) bacteria. He had seven years earlier named the genus Bacterium. Bacillus
Bacillus
was later amended by Ferdinand Cohn to further describe them as spore-forming, Gram-positive, aerobic or facultatively anaerobic bacteria.[1] Like other genera associated with the early history of microbiology, such as Pseudomonas
Pseudomonas
and Vibrio, the 266 species of Bacillus
Bacillus
are ubiquitous.[10] The genus has a very large ribosomal 16S diversity and is environmentally diverse. Several studies have tried to reconstruct the phylogeny of the genus. The Bacillus-specific study with the most diversity covered is by Xu and Cote using 16S and the ITS regions, where they divide the genus into 10 groups, which includes the nested genera Paenibacillus, Brevibacillus, Geobacillus, Marinibacillus and Virgibacillus.[11] However, the tree[12] constructed by the living tree project, a collaboration between ARB-Silva and LPSN where a 16S (and 23S if available) tree of all validated species was constructed,[13][14] the genus Bacillus
Bacillus
contains a very large number of nested taxa and majorly in both 16S and 23S it is paraphyletic to the Lactobacillales (Lactobacillus, Streptococcus, Staphylococcus, Listeria, etc.), due to Bacillus coahuilensis and others. A gene concatenation study found similar results to Xu and Cote, but with a much more limited number of species in terms of groups,[15] but used Listeria
Listeria
as an outgroup, so in light of the ARB tree, it may be "inside-out". One clade, formed by B. anthracis, B. cereus, B. mycoides, B. pseudomycoides, B. thuringiensis, and B. weihenstephanensis under current classification standards, should be a single species (within 97% 16S identity), but due to medical reasons, they are considered separate species,[16]:34–35 an issue also present for four species of Shigella
Shigella
and Escherichia coli.[17]

Bacillus
Bacillus
phylogenetics

Root

"pathogenic"

Bacillus
Bacillus
weihenstephanensis

Bacillus
Bacillus
cereus/thuringiensis/anthracis

"soil"

Bacillus
Bacillus
pumilus

Bacillus
Bacillus
subtilis

Bacillus
Bacillus
licheniformis

"benthic"

Geobacillus kaustophilus

"aquatic"

Bacillus
Bacillus
coahuilensis

Bacillus
Bacillus
sp. m3-13

Bacillus
Bacillus
sp. NRRLB-14911

"benthic"

Oceanobacillus iheyensis

"halophiles"

Bacillus
Bacillus
halodurans

Bacillus
Bacillus
clausii

Phylogeny of the genus Bacillus
Bacillus
according to [15]

See also[edit]

Paenibacillus
Paenibacillus
and Virgibacillus, genera of bacteria formerly included in Bacillus.[18][19]

References[edit]

^ a b (in German) Cohn F.: Untersuchungen über Bakterien. Beitrage zur Biologie der Pflanzen Heft 2, 1872, 1, 127-224. ^ Loshon, Charles A.; Beary, Katherine E.; Gouveia, Kristine; Grey, Elizabeth Z.; Santiago-Lara, Leticia M.; Setlow, Peter (March 1998). "Nucleotide sequence of the sspE genes coding for γ-type small, acid-soluble spore proteins from the round-spore-forming bacteria Bacillus
Bacillus
aminovorans, Sporosarcina halophila and S. ureae". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1396 (2): 148–152. doi:10.1016/S0167-4781(97)00204-2.  ^ Turnbull PCB (1996). Baron S; et al., eds. Bacillus. In: Barron's Medical Microbiology (4th ed.). Univ of Texas Medical Branch. ISBN 978-0-9631172-1-2.  ^ Madigan M; Martinko J, eds. (2005). Brock Biology of Microorganisms (11th ed.). Prentice Hall. ISBN 0-13-144329-1.  ^ Graumann P, ed. (2012). Bacillus: Cellular and Molecular Biology (2nd ed.). Caister Academic Press. ISBN 978-1-904455-97-4. [1].  ^ Joan L. Slonczewski & John W. Foster (2011), Microbiology: An Evolving Science (2nd Edition), Norton ^ Jeong, Haeyoung; Jeong, Da-Eun; Kim, Sun Hong; Song, Geun Cheol; Park, Soo-Young; Ryu, Choong-Min; Park, Seung-Hwan; Choi, Soo-Keun (2012-08-01). "Draft Genome Sequence of the Plant Growth-Promoting Bacterium
Bacterium
Bacillus
Bacillus
siamensis KCTC 13613T". Journal of Bacteriology. 194 (15): 4148–4149. doi:10.1128/JB.00805-12. ISSN 0021-9193. PMC 3416560 . PMID 22815459.  ^ Keen, E; Bliskovsky, V; Adhya, S; Dantas, G (2017). "Draft genome sequence of the naturally competent Bacillus
Bacillus
simplex strain WY10". Genome Announcements. 5: e01295–17. doi:10.1128/genomeA.01295-17. PMC 5690344 . PMID 29146837.  ^ Ryan KJ; Ray CG, eds. (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. ISBN 0-8385-8529-9.  ^ Bacillus
Bacillus
entry in LPSN [Euzéby, J.P. (1997). "List of Bacterial Names with Standing in Nomenclature: a folder available on the Internet". Int J Syst Bacteriol. 47 (2): 590–2. doi:10.1099/00207713-47-2-590. ISSN 0020-7713. PMID 9103655. ] ^ Xu, D.; Cote, J. -C. (2003). "Phylogenetic relationships between Bacillus
Bacillus
species and related genera inferred from comparison of 3' end 16S rDNA and 5' end 16S-23S ITS nucleotide sequences". International Journal of Systematic and Evolutionary Microbiology. 53 (3): 695–704. doi:10.1099/Ijs.0.02346-0. PMID 12807189.  ^ http://www.arb-silva.de/fileadmin/silva_databases/living_tree/LTP_release_104/LTPs104_SSU_tree.pdf ^ Yarza, P.; Richter, M.; Peplies, J. R.; Euzeby, J.; Amann, R.; Schleifer, K. H.; Ludwig, W.; Glöckner, F. O.; Rosselló-Móra, R. (2008). "The All- Species
Species
Living Tree project: A 16S rRNA-based phylogenetic tree of all sequenced type strains" (PDF). Systematic and Applied Microbiology. 31 (4): 241–250. doi:10.1016/j.syapm.2008.07.001. PMID 18692976.  ^ Yarza, P.; Ludwig, W.; Euzéby, J.; Amann, R.; Schleifer, K. H.; Glöckner, F. O.; Rosselló-Móra, R. (2010). "Update of the All- Species
Species
Living Tree Project based on 16S and 23S rRNA sequence analyses". Systematic and Applied Microbiology. 33 (6): 291–299. doi:10.1016/j.syapm.2010.08.001. PMID 20817437.  ^ a b Alcaraz, L.; Moreno-Hagelsieb, G.; Eguiarte, L. E.; Souza, V.; Herrera-Estrella, L.; Olmedo, G. (2010). "Understanding the evolutionary relationships and major traits of Bacillus
Bacillus
through comparative genomics". BMC Genomics. 11: 332. doi:10.1186/1471-2164-11-332. PMC 2890564 . PMID 20504335. 1471216411332.  ^ Ole Andreas Økstad and Anne-Brit Kolstø Chapter 2: "Genomics of Bacillus
Bacillus
Species" in M. Wiedmann, W. Zhang (eds.), Genomics of Foodborne Bacterial Pathogens, 29 Food Microbiology and Food Safety. Springer Science+Business Media, LLC 2011 DOI 10.1007/978-1-4419-7686-4_2 ^ Brenner (D.J.): Family I. Enterobacteriaceae Rahn 1937, Nom. fam. cons. Opin. 15, Jud. Com. 1958, 73; Ewing, Farmer, and Brenner 1980, 674; Judicial Commission 1981, 104. In: N.R. Krieg and J.G. Holt (eds), Bergey's Manual of Systematic Bacteriology, first edition, vol. 1, The Williams & Wilkins Co, Baltimore, 1984, pp. 408-420 ^ Ash, Carol; Priest, Fergus G.; Collins, M. David (1994). "Molecular identification of rRNA group 3 bacilli (Ash, Farrow, Wallbanks and Collins) using a PCR probe test". Antonie van Leeuwenhoek. 64 (3–4): 253–260. doi:10.1007/BF00873085.  ^ Heyndrickx, M.; Lebbe, L.; Kersters, K.; De Vos, P.; Forsyth, G.; Logan, N. A. (1 January 1998). "Virgibacillus: a new genus to accommodate Bacillus
Bacillus
pantothenticus (Proom and Knight 1950). Emended description of Virgibacillus pantothenticus". International Journal of Systematic Bacteriology. 48 (1): 99–106. doi:10.1099/00207713-48-1-99. 

External links[edit]

Wikimedia Commons has media related to Bacillus.

Bacillus
Bacillus
genomes and related information at PATRIC, a Bioinformatics Resource Center funded by NIAID

v t e

Firmicutes
Firmicutes
(low-G+C) Infectious diseases Bacterial diseases: G+

primarily A00–A79, 001–041, 080–109

Bacilli

Lactobacillales (Cat-)

Streptococcus

α

optochin susceptible

S. pneumoniae

Pneumococcal infection

optochin resistant

Viridans streptococci: S. mitis S. mutans S. oralis S. sanguinis S. sobrinus milleri group

β

A

bacitracin susceptible: S. pyogenes

Group A streptococcal infection Streptococcal pharyngitis Scarlet fever Erysipelas Rheumatic fever

B

bacitracin resistant, CAMP test+: S. agalactiae

Group B streptococcal infection

ungrouped

Streptococcus
Streptococcus
iniae

Cutaneous Streptococcus
Streptococcus
iniae infection

γ

D BEA+: Streptococcus
Streptococcus
bovis

Enterococcus

BEA+: Enterococcus
Enterococcus
faecalis

Urinary tract infection

Enterococcus
Enterococcus
faecium

Bacillales (Cat+)

Staphylococcus

Cg+

S. aureus

Staphylococcal scalded skin syndrome

Toxic shock syndrome MRSA

Cg-

novobiocin susceptible

S. epidermidis

novobiocin resistant

S. saprophyticus

Bacillus

Bacillus
Bacillus
anthracis

Anthrax

Bacillus
Bacillus
cereus

Food poisoning

Listeria

Listeria
Listeria
monocytogenes

Listeriosis

Clostridia

Clostridium
Clostridium
(spore-forming)

motile:

Clostridium
Clostridium
difficile

Pseudomembranous colitis

Clostridium
Clostridium
botulinum

Botulism

Clostridium
Clostridium
tetani

Tetanus

nonmotile:

Clostridium
Clostridium
perfringens

Gas gangrene Clostridial necrotizing enteritis

Peptostreptococcus
Peptostreptococcus
(non-spore forming)

Peptostreptococcus
Peptostreptococcus
magnus

Mollicutes

Mycoplasmataceae

Ureaplasma urealyticum

Ureaplasma infection

Mycoplasma genitalium Mycoplasma pneumoniae

Mycoplasma pneumonia

Anaeroplasmatales

Erysipelothrix rhusiopathiae

Erysipeloid

Biology portal

Taxon identifiers

Wd: Q212032 EoL: 83228 EPPO: 1BACIG GBIF: 3227637 ITIS: 407 NCBI:

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