The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the

leucine zipper A leucine zipper (or leucine scissors) is a common three-dimensional structural motif in proteins. They were first described by Landschulz and collaborators in 1988 when they found that an enhancer binding protein had a very characteristic 30-amin ...

that is required to hold together (dimerize) two DNA binding regions. The DNA binding region comprises a number of basic amino acids such as

arginine Arginine is the amino acid with the formula (H2N)(HN)CN(H)(CH2)3CH(NH2)CO2H. The molecule features a guanidino group appended to a standard amino acid framework. At physiological pH, the carboxylic acid is deprotonated (−CO2−) and both the am ...

and

lysine Lysine (symbol Lys or K) is an α-amino acid that is a precursor to many proteins. It contains an α-amino group (which is in the protonated form under biological conditions), an α-carboxylic acid group (which is in the deprotonated − ...

. Proteins containing this domain are

transcription factors In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The fun ...

bZIP transcription factors

bZIP transcription factors are found in all eukaryotes and form one of the largest families of dimerizing TFs. An evolutionary study from 2008 revealed that 4 bZIP genes were encoded by the genome of the

most recent common ancestor In biology and genetic genealogy, the most recent common ancestor (MRCA), also known as the last common ancestor (LCA) or concestor, of a set of organisms is the most recent individual from which all the organisms of the set are descended. The ...

of all plants. Interactions between bZIP transcription factors are numerous and complex and play important roles in cancer development in epithelial tissues, steroid hormone synthesis by cells of endocrine tissues, factors affecting reproductive functions, and several other phenomena that affect human health.

bZIP domain containing proteins

* AP-1 fos/ jun heterodimer that forms a

transcription factor In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The f ...

* Jun-B transcription factor *

CREB CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. CREB was first de ...

cAMP response element transcription factor * OPAQUE2 (O2) transcription factor of the 22-kD zein gene that encodes a class of storage proteins in the

endosperm The endosperm is a tissue produced inside the seeds of most of the flowering plants following double fertilization. It is triploid (meaning three chromosome sets per nucleus) in most species, which may be auxin-driven. It surrounds the embryo an ...

of maize (''Zea Mays'') kernels *

NFE2L2 Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the ''NFE2L2'' gene. NRF2 is a basic leucine zipper (bZIP) protein that may regul ...

or Nrf2 * Bzip Maf transcription factors

Human proteins containing this domain

ATF1 Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ''ATF1'' gene. This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. ...

;

ATF2 Activating transcription factor 2, also known as ATF2, is a protein that, in humans, is encoded by the ''ATF2'' gene. Function This gene encodes a transcription factor that is a member of the leucine zipper family of DNA-binding proteins. T ...

;

ATF4 Activating transcription factor 4 (tax-responsive enhancer element B67), also known as ATF4, is a protein that in humans is encoded by the ''ATF4'' gene. Function This gene encodes a transcription factor that was originally identified as a w ...

; ATF5;

ATF6 Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ''ATF6'' gene and is involved in the unfolded protein response. Function ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembr ...

; ATF7;

BACH1 Transcription regulator protein BACH1 is a protein that in humans is encoded by the ''BACH1'' gene. Function This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZ ...

;

BACH2 Transcription regulator protein BACH2 (broad complex-tramtrack-bric a brac and Cap'n'collar homology 2) is a protein that in humans is encoded by the ''BACH2'' gene. It contains a BTB/POZ domain at its N-terminus which forms a disulphide-linked ...

;

BATF The Bureau of Alcohol, Tobacco, Firearms and Explosives (BATFE), commonly referred to as the ATF, is a domestic law enforcement agency within the United States Department of Justice. Its responsibilities include the investigation and prevent ...

;

BATF2 Basic leucine zipper transcription factor, ATF-like 2 is a protein that, in humans, is encoded by the BATF2 gene. References Further reading * * * * * * * Proteins {{gene-11-stub ...

;

CEBPA CCAAT/enhancer-binding protein alpha is a protein encoded by the ''CEBPA'' gene in humans. CCAAT/enhancer-binding protein alpha is a transcription factor involved in the differentiation of certain blood cells. For details on the CCAAT structural ...

;

CEBPB CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the ''CEBPB'' gene. Function The protein encoded by this intronless gene is a bZIP transcription factor that can bind as a homodimer to certain DNA regulatory regi ...

;

CEBPD CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the ''CEBPD'' gene. Function The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory re ...

;

CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CRP1, is a type of ccaat-enhancer-binding protein. CEBPE is its human gene and is pro-apoptotic. The protein encoded by this gene is a bZIP transcription factor which can ...

;

CEBPG CCAAT/enhancer-binding protein gamma is a protein that in humans is encoded by the ''CEBPG'' gene. The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain th ...

;

CEBPZ CCAAT/enhancer-binding protein zeta is a protein that in humans is encoded by the ''CEBPZ'' gene. Interactions CCAAT/enhancer binding protein zeta has been shown to interact with: * NFYB, * P53, * P73 See also * Ccaat-enhancer-binding ...

;

CREB1 CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the ''CREB1'' gene. This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. ...

; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREB5;

CREBL1 CAMP responsive element binding protein-like 1, also known as CREBL1, is a protein which in humans is encoded by the ''CREBL1'' gene. Function The protein encoded by this gene bears sequence similarity with the Creb/ATF subfamily of the bZip ...

; CREM; E4BP4;

FOSL1 Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the ''FOSL1'' gene. Function The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with ...

;

FOSL2 Fos-related antigen 2 (FRA2) is a protein that in humans is encoded by the ''FOSL2'' gene. Function The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with p ...

; JUN;

JUNB Transcription factor jun-B is a protein that in humans is encoded by the ''JUNB'' gene. Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA se ...

;

JUND Under the early Caliphates, a ''jund'' ( ar, جند; plural ''ajnad'', اجناد) was a military division, which became applied to Arab military colonies in the conquered lands and, most notably, to the provinces into which Greater Syria (the Le ...

; MAFA; MAFB;

MAFF MAFF may refer to: * MAFF (gene), a transcription factor * Malmö Arab Film Festival, held in Malmö (Sweden), the largest Arabic film festival in Europe * Ministry of Agriculture, Fisheries and Food (United Kingdom), a former department of UK g ...

;

MAFG Transcription factor MafG is a bZip Maf transcription factor protein that in humans is encoded by the ''MAFG'' gene. MafG is one of the small Maf proteins, which are basic region and leucine zipper (bZIP)-type transcription factors. The HUGO Ge ...

; NRL; C-MAF;

MAFK #REDIRECT MAFK {{R from alternative capitalization ...

;

NFE2 __NOTOC__ Transcription factor NF-E2 45 kDa subunit is a protein that in humans is encoded by the ''NFE2'' gene. It is involved in megakaryocyte production. Interactions NFE2 has been shown to interact with CREB-binding protein Cyclic aden ...

;

; NFE2L3; SNFT; XBP1

References

External links

bZIP domain entry
in the SMART database
bZIP family
a
PlantTFDB: Plant Transcription Factor DatabasePlant bZIP transcription factors
{{DEFAULTSORT:Bzip Domain Protein domains DNA-binding proteins