BD1031 or (R)-2-

-(3,4-dichlorophenyl)ethyl The hyphen-minus is the most commonly used type of hyphen, widely used in digital documents. It is the only character that looks like a minus sign or a dash in many character sets such as ASCII or on most keyboards, so it is also used as s ...

ctahydropyrrolo

,2-a The comma is a punctuation mark that appears in several variants in different languages. It has the same shape as an apostrophe or single closing quotation mark () in many typefaces, but it differs from them in being placed on the baseline o ...

yrazine is a selective sigma receptor

agonist An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...

, with a reported

binding affinity In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. The etymology stems from ''ligare'', which means 'to bind'. In protein-ligand binding, the ligand is usually a mol ...

of ''K''_i = 1 ± 0.2 nM for the sigma-1 receptor and 80 times selectivity over the sigma-2 receptor. The enantiomer of BD1031 is known as

BD1018 BD1018 or (S)-2- -(3,4-dichlorophenyl)ethylctahydropyrrolo ,2-ayrazine is a selective sigma receptor ligand, with a reported binding affinity of ''K''i = 5 ± 0.7 nM for the sigma-1 receptor and approximately 10 times selectivity over the sigma-2 ...

. Consistent with other reported sigma receptor

s, BD1031 increases the behavioural toxicity of cocaine in Swiss Webster mice.

References

{{Sigma receptor modulators Sigma agonists

See also

References