Basic leucine zipper transcription factor, ATF-like, also known as BATF, is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
which in humans is encoded by the ''BATF''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
The protein encoded by this gene is a nuclear basic leucine zipper (
bZIP
The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required to hold tog ...
) protein that belongs to the
AP-1/
ATF superfamily of
transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The f ...
s. The leucine zipper of this protein mediates dimerization with members of the
Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events.
Mice without the BATF gene (BATF
knockout mice) lacked a type of inflammatory immune cell (
Th17) and were resistant to conditions that normally induces an autoimmune condition similar to
multiple sclerosis.
[
*]
Interactions
BATF (gene) has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
IFI35.
References
Further reading
*
*
*
*
*
*
*
*
*
External links
*
*
*
Transcription factors
{{gene-14-stub