Brain-specific angiogenesis inhibitor 1-associated protein 2 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''BAIAP2''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (
BAI1)-binding protein. This interaction at the cytoplasmic membrane is crucial to the function of this protein, which may be involved in neuronal growth-cone guidance. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. This protein has also been identified as interacting with the
dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. Alternative splicing of the 3'-end of this gene results in three products of undetermined function.
Interactions
BAIAP2 has been shown to
interact with:
*
ATN1,
*
CDC42,
EPS8
Epidermal growth factor receptor kinase substrate 8 is an enzyme that in humans is encoded by the ''EPS8'' gene.
Function
This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as par ...
,[
* ]SHANK1
SH3 and multiple ankyrin repeat domains protein 1 is a protein that in humans is encoded by the ''SHANK1'' gene.
Interactions
SHANK1 has been shown to interact with:
* ARHGEF7,
* BAIAP2,
* DNM2,
* SPTAN1
Alpha II-spectrin, also known as S ...
,[
]
References
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{{PDB Gallery, geneid=10458