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Axon
Axon
terminals (also called synaptic boutons) are distal terminations of the branches of an axon . An axon nerve fiber is a long, slender projection of a nerve cell, or neuron , that conducts electrical impulses (called "action potentials") away from the neuron's cell body , or soma, in order to transmit those impulses to other neurons.

Neurons are interconnected in complex arrangements, and use electrochemical signals and neurotransmitter chemicals to transmit impulses from one neuron to the next; axon terminals are separated from neighboring neurons by a small gap called a synapse , across which impulses are sent. The axon terminal, and the neuron from which it comes, is sometimes referred to as the "presynaptic" neuron.

CONTENTS

* 1 Nerve impulse release * 2 Mapping activity * 3 See also * 4 References * 5 Further reading

NERVE IMPULSE RELEASE

Neurotransmitters
Neurotransmitters
are packaged into synaptic vesicles that cluster beneath the axon terminal membrane on the presynaptic side of a synapse. The axonal terminals are specialized to release the neurotransmitters of the presynaptic cell. The terminals release transmitter substances into a gap called the synaptic cleft between the terminals and the dendrites of the next neuron. The information is received by the dendrite receptors of the postsynaptic cell that are connected to it. Neurons don't touch each other, but communicate across the synapse .

The neurotransmitter molecule packages (vesicles) are created within the neuron, then travel down the axon to the distal axon terminal where they sit docked . Calcium
Calcium
ions then trigger a biochemical cascade which results in vesicles fusing with the presynaptic membrane and releasing their contents to the synaptic cleft within 180 µs of calcium entry. Triggered by the binding of the calcium ions, the synaptic vesicle proteins begin to move apart, resulting in the creation of a fusion pore . The presence of the pore allows for the release of neurotransmitter into the synaptic cleft. The process occurring at the axon terminal is exocytosis , which a cell uses to exude secretory vesicles out of the cell membrane . These membrane-bound vesicles contain soluble proteins to be secreted to the extracellular environment, as well as membrane proteins and lipids that are sent to become components of the cell membrane. Exocytosis
Exocytosis
in neuronal chemical synapses is Ca2+ triggered and serves interneuronal signalling.

MAPPING ACTIVITY

Structure of a typical neuron NEURON

Dendrite
Dendrite
Soma Axon
Axon
Nucleus Node of Ranvier Axon
Axon
terminal Schwann cell
Schwann cell
Myelin
Myelin
sheath

Dr. Wade Regehr , a Professor
Professor
of Neurobiology
Neurobiology
at Harvard Medical School 's Department of Neurobiology
Neurobiology
, developed a method to physiologically see the synaptic activity that occurs in the brain. A dye alters the fluorescence properties when attached to calcium. Using fluorescence-microscopy techniques calcium levels are detected, and therefore the influx of calcium in the presynaptic neuron . Regehr's laboratory specializes in pre-synaptic calcium dynamics which occurs at the axon terminals. Regehr studies the implication of calcium Ca2+ as it affects synaptic strength. By studying the physiological process and mechanisms, a further understanding is made of neurological disorders such as epilepsy , schizophrenia and major depressive disorder , as well as memory and learning .

SEE ALSO

* Telodendron * Endoplasmic reticulum
Endoplasmic reticulum
* Golgi apparatus
Golgi apparatus
* Micelle
Micelle
* Membrane nanotube * Endocytosis
Endocytosis
* Synaptic vesicle * Vesicle (biology)
Vesicle (biology)
* Chemical synapse
Chemical synapse
* Vesicular monoamine transporter
Vesicular monoamine transporter
* Axon
Axon

REFERENCES

* ^ " Axon
Axon
Terminal". Medical Dictionary Online. Retrieved February 6, 2013. * ^ Foster, Sally. " Axon
Axon
Terminal - Synaptic Vesicle - Neurotransmitter". Retrieved February 6, 2013. * ^ Llinás R, Steinberg IZ, Walton K (1981). "Relationship between presynaptic calcium current and postsynaptic potential in squid giant synapse" . Biophysical Journal. 33 (3): 323–51. PMC 1327434  . PMID 6261850 . doi :10.1016/S0006-3495(81)84899-0 . * ^ Carlson, 2007, p.56 * ^ Chudler, Eric H. (November 24, 2011). "Neuroscience for kids Neurotransmitters
Neurotransmitters
and Neuroactive Peptides". Archived from the original on December 18, 2008. Retrieved February 6, 2013. * ^ Sauber, Colleen. "Focus October 20- Neurobiology
Neurobiology
VISUALIZING THE SYNAPTIC CONNECTION". Archived from the original on 2006-09-01. Retrieved July 3, 2013. * ^ Regehr, Wade (1999–2008). "Wade Regehr, Ph.D.". Archived from the original on February 18, 2010. Retrieved July 3, 2013. * ^ President and Fellows of Harvard College (2008). "The Neurobiology
Neurobiology
Department at Harvard Medical School". Archived from the original on 20 December 2008. Retrieved July 3, 2013. * ^ "NINDS Announces New Javits Neuroscience Investigator Awardees" (Press release). National Institute of Neurological Disorders and Stroke . May 4, 2005. Archived from the original on January 17, 2009. Retrieved February 6, 2013. * ^ "Scholar Awards". The McKnight Endowment Fund for Neuroscience. Archived from the original on 2004-05-08. Retrieved July 3, 2013.

FURTHER READING

* Cragg, Stephanie J.; Greenfield, Susan A. (1997). "Differential Autoreceptor Control of Somatodendritic and Axon
Axon
Terminal Dopamine Release in Substantia Nigra, Ventral Tegmental Area, and Striatum". The Journal of Neuroscience. 17 (15): 5738–46. PMID 9221772 . * Vaquero, Cecilia F; de la Villa, Pedro (1999). "Localisation of the GABAC receptors at the axon terminal of the rod bipolar cells of the mouse retina". Neuroscience Research. 35 (1): 1–7. PMID 10555158 . doi :10.1016/S0168-0102(99)00050-4 . * Roffler-Tarlov, Suzanne; Beart, P.M.; O'Gorman, Stephen; Sidman, Richard L. (1979). "Neurochemical and morphological consequences of axon terminal degeneration in cerebellar deep nuclei of mice with inherited purkinje cell degeneration". Brain Research. 168 (1): 75–95. PMID 455087 . doi :10.1016/0006-8993(79)90129-X . * Yagi T, Kaneko A (1988). "The axon terminal of goldfish retinal horizontal cells: A low membrane conductance measured in solitary preparations and its implication to the signal conduction from the soma". Journal of Neurophysiology. 59 (2): 482–94. PMID 3351572 .

* v * t * e

Membrane transport

Mechanisms for chemical transport through biological membranes

PASSIVE TRANSPORT

* Simple diffusion
Simple diffusion
(or non-mediated transport ) * Facilitated diffusion * Osmosis
Osmosis
* Channels * Carriers

ACTIVE TRANSPORT

* Uniporter * Symporter * Antiporter
Antiporter
* Primary active transport * Secondary active transport

CYTOSIS

ENDOCYTOSIS

* Efferocytosis * Non-specific, adsorptive pinocytosis
Non-specific, adsorptive pinocytosis
* Phagocytosis
Phagocytosis
* Pinocytosis
Pinocytosis
* Potocytosis * Receptor-mediated endocytosis * Transcytosis

EXOCYTOSIS Degranulation

* v * t * e

Nervous tissue
Nervous tissue

CNS

TISSUE TYPES

* Grey matter
Grey matter

* White matter
White matter

* Projection fibers * Association fiber
Association fiber
* Commissural fiber
Commissural fiber
* Lemniscus * Funiculus * Fasciculus * Nerve tract
Nerve tract
* Decussation
Decussation
* Commissure

* Neuropil
Neuropil
* Meninges
Meninges

CELL TYPES

NEURONAL

* Pyramidal * Purkinje * Granule

GLIAL

INSULATING:

* Myelination : Oligodendrocyte
Oligodendrocyte

OTHER

* Astrocyte
Astrocyte

* Radial glial cell
Radial glial cell

* Ependymal cells

* Tanycyte
Tanycyte

* Microglia
Microglia

PNS

GENERAL

* Dorsal

* Root * Ganglion * Ramus

* Ventral

* Root * Ramus

* Ramus communicans
Ramus communicans

* Gray * White

* Autonomic ganglion ( Preganglionic nerve fibers * Postganglionic nerve fibers )

CONNECTIVE TISSUES

* Epineurium * Perineurium * Endoneurium
Endoneurium
* Nerve fascicle
Nerve fascicle

NEUROGLIA

* Myelination : Schwann cell
Schwann cell

* Neurolemma * Myelin
Myelin
incisure * Node of Ranvier
Node of Ranvier
* Internodal segment

* Satellite glial cell

Neurons / nerve fibers

PARTS

SOMA

* Axon
Axon
hillock

AXON

* Telodendron * Axon
Axon
terminals * Axoplasm * Axolemma * Neurofibril/neurofilament

DENDRITE

*

* Nissl body
Nissl body
* Dendritic spine
Dendritic spine
* Apical dendrite / Basal dendrite

TYPES

* Bipolar * Unipolar * Pseudounipolar * Multipolar

* Interneuron
Interneuron

* Renshaw

Afferent nerve fiber
Afferent nerve fiber
/ Sensory neuron
Sensory neuron

* GSA * GVA * SSA * SVA

* fibers

* Ia * Ib or Golgi * II or Aβ * III or Aδ or fast pain * IV or C or slow pain

Efferent nerve fiber
Efferent nerve fiber
/ Motor neuron
Motor neuron

* GSE * GVE * SVE * Upper motor neuron
Upper motor neuron

* Lower motor neuron

* α motorneuron * β motorneuron * γ motorneuron

TERMINATION

SYNAPSE

* Electrical synapse
Electrical synapse
/ Gap junction
Gap junction

* Chemical synapse
Chemical synapse

* Synaptic vesicle * Active zone
Active zone
* Postsynaptic density
Postsynaptic density

* Autapse * Ribbon synapse * Neuromuscular junction
Neuromuscular junction

SENSORY RECEPTORS

* Meissner\'s corpuscle * Merkel nerve ending * Pacinian corpuscle * Ruffini ending * Muscle spindle * Free nerve ending * Nociceptor
Nociceptor
* Olfactory receptor neuron
Olfactory receptor neuron
* Photoreceptor cell
Photoreceptor cell
* Hair cell
Hair cell
*

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