The Atlas of Genetics and Cytogenetics in Oncology and Haematology, created in 1997 by

Jean-Loup Huret Jean Loup Huret (born 1951) is a French scientist and medical practitioner specialist in genetics, honorary associate professor of medical genetics of the French Universities, working on chromosome abnormalities. Huret has discovered the first cas ...

(with bioinformatics by Philippe Dessen) is a collection of resources on

gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

s, chromosomes anomalies,

leukemia Leukemia ( also spelled leukaemia and pronounced ) is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. These blood cells are not fully developed and are called ''blasts'' or ' ...

solid tumour A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists ...

s, and

cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...

-prone diseases. The project is accessible through Internet and is made of encyclopedic-style files, as well as traditional overviews, links towards websites and databases devoted to cancer and/or genetics, case reports in

haematology Hematology ( always spelled haematology in British English) is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to blood. It involves treating diseases that affect the produc ...

. It also encompasses teaching items in various languages. Starting first from cytogenetics in the nineteens, the Atlas now combines different types of knowledge in a single web site: genes and their function, cell biology (ex: Apoptosis), pathological data, diseases and their clinical implications, cytogenetics, but also medical genetics, with hereditary disorders associated with an increased risk of cancer. This gives a wider and more global view of cancer genetics, while these data are usually dispersed. It includes a large iconography of about 35,000 images. Dan van Dyke said "This is one stop shopping that unifies cancer genetics information", and Lidia Larizza said that the Atlas was an "interdisciplinary resource". Felix Mitelman said "This systematic collection of cytogenetic and genetic aberrations (…) the molecular outcome (…) and the clinical consequences (….) has grown into a truly monumental encyclopedic work of great importance";

Janet Rowley Janet Davison Rowley (April 5, 1925 – December 17, 2013) was an American human geneticist and the first scientist to identify a chromosomal translocation as the cause of leukemia and other cancers, thus proving that cancer is a genetic disease. ...

said: "In the future I will undoubtedly rely on your Website rather than trying to keep up with the literature myself" The Atlas is part of the

genome project Genome projects are scientific endeavours that ultimately aim to determine the complete genome sequence of an organism (be it an animal, a plant, a fungus, a bacterium, an archaean, a protist or a virus) and to annotate protein-coding genes and ot ...

and participates in research on

cancer epidemiology The epidemiology of cancer is the study of the factors affecting cancer, as a way to infer possible trends and causes. The study of cancer epidemiology uses epidemiological methods to find the cause of cancer and to identify and develop improve ...

. The Atlas is accessed by: 1- researchers in

cytogenetics Cytogenetics is essentially a branch of genetics, but is also a part of cell biology/cytology (a subdivision of human anatomy), that is concerned with how the chromosomes relate to cell behaviour, particularly to their behaviour during mitosis an ...

molecular biology Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physi ...

cell biology Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living and ...

; 2- clinicians, haematologists, cytogeneticists, pathologists, from the university hospitals, indeed, but also from general hospitals where the Atlas is one of the rare free resources. Junior doctors in haematology or oncology, are also most receptive to the Atlas that they see as a training and educational tool; 3-Students in medicine and life sciences. In 2017, it contains review articles on 1,500 genes, 700 papers on leukemias, 220 on solid tumors, and 110 on hereditary disease with a cancer-prone condition and 110 "Deep Insights" on related subjects, 40,000 internal links and 730,000 external links. This represents 45,000 "web pages" (i.e. about 200,000 printed pages). More than 3,300 authors have/are contributing (1 130 North-American, 400 French, 300 Italian, 200 Japanese, 180 Spanish, 170 German, 160 English, 140 Chinese, etc...) . It includes an iconography of about 35,000 images. In 2018, Jesús María Hernández Rivas (Salamanca, Spain) and Paola Dal Cin (Boston, Massachusetts) joined Jean-Loup Huret as Co-Editors in Chief, and in April 2021 Alessandro Beghini (Milano, Italy) and João Agostinho Machado-Neto (São Paulo, Brazil) replace Jean-Loup Huret. "After 25 years building the Atlas day after day, Jean-Loup Huret and Philippe Dessen will take a little rest", as is said on the web site. The Atlas is also published as a scientific journal by CNRS, and is referenced by

Scopus Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-l ...

et Embase. The Atlas is financially supported by scientific societies, charities and individual donations. More data is available from the site of the association in charge of the Atlas.

References

Sources

* {{cite journal , last1=Brooksbank , first1=Cath , title=Chopping and changing , journal=Nature Reviews Cancer , date=December 2001 , volume=1 , issue=3 , pages=179 , doi=10.1038/35106056 , s2cid=29705598 , doi-access=free

External links

The database
(atlasgeneticsoncology.org)
Scientific Journal
(irevues.inist.fr/atlasgeneticsoncology)
OxfordJournals.org

On MedMatrix
Genetics journals

See also

References

Sources

External links