The aryl-hydrocarbon receptor repressor also known as AHRR is a human gene.
Dioxins and dioxin-like compounds are teratogens that exert their effects through the aryl hydrocarbon receptor (AhR) in conjunction with the receptor's binding partner, aryl hydrocarbon receptor nuclear translocator (ARNT). The protein encoded by this gene represses signal transduction by the AhR by competing with the arylhydrocarbon receptor for binding to the ARNT. Expression of the repressor is stimulated by the receptor/translocator heterodimer, thereby regulating receptor function through a negative feedback mechanism. In addition, the encoded protein can bind to nuclear factor-kappa B.
The AhRR gene may act as a tumor suppressor.
The expression of AhRR is high in testis, lung, ovary, spleen and pancreas in adults, whereas expression is low in all tissues in fetuses.
- ^ Baba T, Mimura J, Gradin K, Kuroiwa A, Watanabe T, Matsuda Y, Inazawa J, Sogawa K, Fujii-Kuriyama Y (August 2001). "Structure and expression of the Ah receptor repressor gene". J. Biol. Chem. 276 (35): 33101–10. doi:10.1074/jbc.M011497200. PMID 11423533.
- ^ Evans BR, Karchner SI, Allan LL, Pollenz RS, Tanguay RL, Jenny MJ, Sherr DH, Hahn ME (February 2008). "Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator". Mol. Pharmacol. 73 (2): 387–98. doi:10.1124/mol.107.040204. PMC 3263532 . PMID 18000031.
- ^ Zudaire E, Cuesta N, Murty V, Woodson K, Adams L, Gonzalez N, Martínez A, Narayan G, Kirsch I, Franklin W, Hirsch F, Birrer M, Cuttitta F (February 2008). "The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers". J. Clin. Invest. 118 (2): 640–50. doi:10.1172/JCI30024. PMC 2157559 . PMID 18172554.
- ^ Kanno Y, Takane Y, Izawa T, Nakahama T, Inouye Y (June 2006). "The Inhibitory Effect of Aryl Hydrocarbon Receptor Repressor (AhRR) on the Growth of Human Breast Cancer MCF-7 Cells". Biol. Pharm. Bull. 29 (6): 1254–7. doi:10.1248/bpb.29.1254. PMID 16755028.
- ^ Yamamoto J, Ihara K, Nakayama H, Hikino S, Satoh K, Kubo N, Iida T, Fujii Y, Hara T (January 2004). "Characteristic expression of aryl hydrocarbon receptor repressor gene in human tissues: organ-specific distribution and variable induction patterns in mononuclear cells". Life Sci. 74 (8): 1039–49. doi:10.1016/j.lfs.2003.07.022. PMID 14672759.