Arthur John Birch, AC CMG FRS FAA (3 August 1915 – 8 December 1995) was an Australian

organic chemist Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J. ...

. Birch developed the

Birch reduction The Birch reduction is an organic reaction that is used to convert arenes to cyclohexadienes. The reaction is named after the Australian chemist Arthur Birch and involves the organic reduction of aromatic rings in an amine solvent (traditionally ...

aromatic rings In chemistry, aromaticity is a chemical property of cyclic ( ring-shaped), ''typically'' planar (flat) molecular structures with pi bonds in resonance (those containing delocalized electrons) that gives increased stability compared to saturat ...

(by treatment with

lithium metal Lithium (from el, λίθος, lithos, lit=stone) is a chemical element with the symbol Li and atomic number 3. It is a soft, silvery-white alkali metal. Under standard conditions, it is the least dense metal and the least dense solid ele ...

and

ammonia Ammonia is an inorganic compound of nitrogen and hydrogen with the formula . A stable binary hydride, and the simplest pnictogen hydride, ammonia is a colourless gas with a distinct pungent smell. Biologically, it is a common nitrogenous ...

) which is widely used in

synthetic organic chemistry Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J ...

. The Birch Reduction enables the modification of

steroid A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter membrane fluidity; and ...

s. In 1948 Birch published the first total synthesis of a

male sex hormone Sex hormones, also known as sex steroids, gonadocorticoids and gonadal steroids, are steroid hormones that interact with vertebrate steroid hormone receptors. The sex hormones include the androgens, estrogens, and progestogens. Their effects are ...

(

19-nortestosterone Nandrolone, also known as 19-nortestosterone, is an androgen and anabolic steroid (AAS) which is used in the form of esters such as nandrolone decanoate (brand name Deca-Durabolin) and nandrolone phenylpropionate (brand name Durabolin). Nandrolon ...

), as the first member of a new structural series. This series later comprised the first oral contraceptive pill, which was made by others. The Birch reduction also allows for the development of other

drugs and

antibiotic An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention ...

s – he also made the first simple synthesis of the ring A-B structure of

cholesterol Cholesterol is any of a class of certain organic molecules called lipids. It is a sterol (or modified steroid), a type of lipid. Cholesterol is biosynthesized by all animal cells and is an essential structural component of animal cell memb ...

. Birch published over 440 scientific papers and reports.

Early life and education

Birch won a scholarship to attend the

University of Sydney The University of Sydney (USYD), also known as Sydney University, or informally Sydney Uni, is a public research university located in Sydney, Australia. Founded in 1850, it is the oldest university in Australia and is one of the country's si ...

graduating with a BSc in 1937 and a MSc in 1938. He travelled to the

University of Oxford , mottoeng = The Lord is my light , established = , endowment = £6.1 billion (including colleges) (2019) , budget = £2.145 billion (2019–20) , chancellor ...

to undertake his

D.Phil. A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is ...

, graduating in 1940.

Career

The hormone research he became involved with in 1940 was initiated by the

RAF The Royal Air Force (RAF) is the United Kingdom's air and space force. It was formed towards the end of the First World War on 1 April 1918, becoming the first independent air force in the world, by regrouping the Royal Flying Corps (RFC) and ...

who then believed German fighter pilots were given cortical hormones He remained a research Fellow at Oxford until 1948 working under Sir Robert Robinson, when he became the Smithson Fellow at the

University of Cambridge , mottoeng = Literal: From here, light and sacred draughts. Non literal: From this place, we gain enlightenment and precious knowledge. , established = , other_name = The Chancellor, Masters and Schola ...

where he remained until 1952. At Cambridge he worked with Lord Todd. He returned to Australia in 1952 to take up a Professorship in organic chemistry at the University of Sydney, he was made a

fellow of the Australian Academy of Science The Fellowship of the Australian Academy of Science is made up of about 500 Australian scientists. Scientists judged by their peers to have made an exceptional contribution to knowledge in their field may be elected to Fellowship of the Academy ...

in 1954. He held his position at the University of Sydney until 1955 when he took a similar position at

Manchester University , mottoeng = Knowledge, Wisdom, Humanity , established = 2004 – University of Manchester Predecessor institutions: 1956 – UMIST (as university college; university 1994) 1904 – Victoria University of Manchester 1880 – Victoria Univer ...

. He was made a

Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural knowledge, including mathemati ...

in 1958. Birch returned to Australia again in 1967 to establish the Research School of Chemistry at the

Australian National University The Australian National University (ANU) is a public research university located in Canberra, the capital of Australia. Its main campus in Acton encompasses seven teaching and research colleges, in addition to several national academies an ...

Canberra Canberra ( ) is the capital city of Australia. Founded following the federation of the colonies of Australia as the seat of government for the new nation, it is Australia's largest inland city and the eighth-largest city overall. The ci ...

, becoming its founding dean. He remained involved with the school until 1980. He served as President of the

Royal Australian Chemical Institute The Royal Australian Chemical Institute (RACI) is both the qualifying body in Australia for professional chemists and a learned society promoting the science and practice of chemistry in all its branches. The RACI hosts conferences, seminars and ...

from 1977 to 1978, and also chaired the 1977 Independent Inquiry into

CSIRO The Commonwealth Scientific and Industrial Research Organisation (CSIRO) is an Australian Government agency responsible for scientific research. CSIRO works with leading organisations around the world. From its headquarters in Canberra, CSIRO ...

. He served as President of the Australian Academy of Science from 1982 to 1986. Birch was made a Companion of the

Order of Australia The Order of Australia is an honour that recognises Australian citizens and other persons for outstanding achievement and service. It was established on 14 February 1975 by Elizabeth II, Queen of Australia, on the advice of the Australian Go ...

(AC) in 1987 for his contributions to science in Australia. He was awarded Honorary Fellowship of the Royal Australian Chemical Institute, in 1994. He was also a founding member of the Australian Science and Technology Council. Before his death in 1995, the Research School of Chemistry building at ANU was named the "Birch Building" in his honour.History of the Research School of Chemistry
ANU

References

External links

{{DEFAULTSORT:Birch, Arthur John 1915 births 1995 deaths Chemists at the University of Cambridge Australian chemists Companions of the Order of Australia Fellows of the Australian Academy of Science Fellows of the Royal Society Foreign Members of the USSR Academy of Sciences Foreign Members of the Russian Academy of Sciences Organic chemists Alumni of the University of Oxford University of Sydney alumni University of Sydney faculty Presidents of the Australian Academy of Science