Arnold Jay Levine (born 1939), is an American

Molecular biologist Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physi ...

. He was awarded the 1998 Louisa Gross Horwitz Prize for Biology or Biochemistry and was the first recipient of the Albany Medical Center Prize in Medicine and Biomedical Research in 2001 for his discovery of the tumor suppressor protein

p53 p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often s ...

. He is currently Professor Emeritus of Systems Biology at the

Institute for Advanced Study The Institute for Advanced Study (IAS), located in Princeton, New Jersey, in the United States, is an independent center for theoretical research and intellectual inquiry. It has served as the academic home of internationally preeminent scholar ...

in Princeton, New Jersey.

Career

Levine received his Ph.D. from the

University of Pennsylvania The University of Pennsylvania (also known as Penn or UPenn) is a private research university in Philadelphia. It is the fourth-oldest institution of higher education in the United States and is ranked among the highest-regarded universitie ...

in 1966. Levine discovered, with several colleagues, the

tumor suppressor gene A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell during cell division and replication. If the cell grows uncontrollably, it will result in cancer. When a tumor suppressor gene is mutated, it results in a loss or red ...

in 1979, a protein involved in

cell cycle The cell cycle, or cell-division cycle, is the series of events that take place in a cell that cause it to divide into two daughter cells. These events include the duplication of its DNA (DNA replication) and some of its organelles, and subs ...

regulation, and one of the most frequently mutated genes in human cancer, in work done as a professor in the biochemistry department at

Princeton University Princeton University is a private university, private research university in Princeton, New Jersey. Founded in 1746 in Elizabeth, New Jersey, Elizabeth as the College of New Jersey, Princeton is the List of Colonial Colleges, fourth-oldest ins ...

. In 1979 Levine moved to become Chairman of the Department of Microbiology at

Stony Brook School of Medicine The Renaissance School of Medicine (RSOM) is the graduate medical school of Stony Brook University located in the hamlet of Stony Brook on Long Island, New York. Founded in 1971, RSOM is consistently ranked the top public medical school in New ...

before moving back to Princeton in 1984. In 1998 Levine became the Robert and Harriet Heilbrunn Professor of Cancer Biology and President of

Rockefeller University The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classif ...

. In 2002, Levine resigned the presidency following allegations that he had an inappropriate sexual encounter with a female graduate student, while both were intoxicated. According to the woman involved, the encounter was consensual and blown out of proportion. In 2002 he was appointed professor at The Cancer Institute of New Jersey in New Brunswick, New Jersey, then a part of the

Robert Wood Johnson Medical School Rutgers Robert Wood Johnson Medical School is a medical school of Rutgers University. It is one of the two graduate medical schools of Rutgers Biomedical and Health Sciences, together with New Jersey Medical School, and is closely aligned with Ro ...

. Simultaneous to this appointment, in 2003, Levine became a visiting professor, then professor, in the newly created Simons Center for Systems Biology at the

(IAS) in Princeton, New Jersey, where he has remained since. In 2017, Levine, with collaborators Benjamin Greenbaum, and Marta Luksza, developed the first mathematical model for predicting patient response to immunotherapy. Their recent work extends to studying immune resistance mechanisms and patterns of evolution.

Award and honors

In addition to the

Louisa Gross Horwitz Prize The Louisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers who have made an outstanding contribution in basic research in the fields of biology or biochemist ...

(

Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...

) (1998) and the inaugural

Albany Medical Center Prize The Albany Medical Center Prize in Medicine and Biomedical Research is the United States' second highest value prize in medicine and biomedical research, awarded by the Albany Medical Center. Among prizes for medicine worldwide, the Albany Medical ...

in 2001, Levine has received numerous awards and honors. He was elected a Member of the U.S. National Academy of Sciences in 1991, a Member of the

Institute of Medicine The National Academy of Medicine (NAM), formerly called the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, E ...

in 1995, and a member of the

American Philosophical Society The American Philosophical Society (APS), founded in 1743 in Philadelphia, is a scholarly organization that promotes knowledge in the sciences and humanities through research, professional meetings, publications, library resources, and communit ...

in 2000. He won the Ciba-Drew Award in 1995. The importance of p53 in cancer biology led to a number of cancer-related awards, including the Bristol-Myers Squibb Award for Distinguished Achievement in Cancer Research (1994), the

Charles S. Mott Prize The Charles S. Mott Prize was awarded annually by the General Motors Cancer Research Foundation as one of a trio of scientific prizes entirely devoted to cancer research, the other two being the Charles F. Kettering Prize and the Alfred P. Sloan, J ...

from the General Motors Cancer Research Foundation (1999), the

Keio Medical Science Prize The Keio Medical Science Prize ( Japanese: 慶應医学賞) is a Japanese prize in medical sciences. Introduction The prize is awarded to scientists who made significant contributions to the field of medical sciences or life sciences. And these co ...

(2000), the Memorial Sloan-Kettering Cancer Center's Medal for Outstanding Contributions to Biomedical Research (2000), the Albany Medical Center Prize in Medicine and Biomedical Research (2001), the Dart/NYU Biotechnology Achievement Award in Basic Biotechnology (2008); the American Association for Cancer Research's Kirk A. Landon–AACR Prize for Basic Cancer Research (2008), the American Cancer Society's Medal of Honor (2009), and the Lars Onsager Medal (2012).

References

External links

Arnold Levine CV
{{DEFAULTSORT:Levine, Arnold 1939 births Living people Members of the United States National Academy of Sciences List of members of the Institute of Medicine University of Pennsylvania alumni California Institute of Technology alumni American biochemists Binghamton University alumni Institute for Advanced Study faculty Presidents of Rockefeller University American molecular biologists Human Genome Project scientists Members of the American Philosophical Society Princeton University faculty Fellows of the American Academy of Microbiology Journal of Virology editors

Career

Award and honors

See also

References

External links