Non-human animals in space originally served to test the survivability of spaceflight, before human spaceflights were attempted. Later, other non-human animals were flown to investigate various biological processes and the effects microgravity and space flight might have on them. Bioastronautics is an area of bioengineering research which spans the study and support of life in space. To date, seven national space programs have flown animals into space: the Soviet Union, the United States, France, Argentina, China, Japan and Iran.
A wide variety of non-human animals have been launched into space, including monkeys, dogs, tortoises, and insects. The United States launched flights containing monkeys and primates primarily between 1948-1961 with one flight in 1969 and one in 1985. France launched two monkey-carrying flights in 1967. The Soviet Union and Russia launched monkeys between 1983 and 1996. During the 1950s and 1960s, the Soviet space program used a number of dogs for sub-orbital and orbital space flights. Two tortoises and a variety of insects were the first inhabitants of earth to circle the moon, on the 1968 Zond 5 mission.
Animals had been used in aeronautic exploration since 1783 when the Montgolfier brothers sent a sheep, a duck, and a rooster aloft in a hot air balloon (the duck serving as the experimental control). The limited supply of captured German V-2 rockets led to the U.S. use of high-altitude balloon launches carrying fruit flies, mice, hamsters, guinea pigs, cats, dogs, frogs, goldfish and monkeys to heights of up to 144,000 feet (44,000 m). These high-altitude balloon flights from 1947 to 1960 tested radiation exposure, physiological response, life support and recovery systems. The U.S. high-altitude manned balloon flights occurred in the same time frame, one of which also carried fruit flies.
The first animals sent into space were fruit flies aboard a U.S.-launched V-2 rocket on 20 February 1947 from White Sands Missile Range, New Mexico. The purpose of the experiment was to explore the effects of radiation exposure at high altitudes. The rocket reached 68 miles (109 km) in 3 minutes and 10 seconds, past both the U.S. Air Force 50-mile and the international 100 km definitions of the boundary of space. The Blossom capsule was ejected and successfully deployed its parachute. The fruit flies were recovered alive. Other V-2 missions carried biological samples, including moss.
Albert II, a rhesus monkey, became the first monkey in space on 14 June 1949, in a U.S.-launched V-2, after the failure of the original Albert's mission on ascent. Albert I reached only 30–39 miles (48–63 km) altitude; Albert II reached about 83 miles (134 km). Albert II died on impact after a parachute failure. Numerous monkeys of several species were flown by the U.S. in the 1950s and 1960s. Monkeys were implanted with sensors to measure vital signs, and many were under anesthesia during launch. The death rate among monkeys at this stage was very high: about two-thirds of all monkeys launched in 1940s and 1950s died on missions or soon after landing.
On 31 August 1950, the U.S. launched a mouse into space (137 km) aboard a V-2 (the Albert V flight, which, unlike the Albert I-IV flights, did not have a monkey), but the rocket disintegrated because the parachute system failed. The U.S. launched several other mice in the 1950s.
On 22 July 1951, the Soviet Union launched the R-1 IIIA-1 flight, carrying the dogs Tsygan (Russian: Цыган, "Gypsy") and Dezik (Russian: Дезик) into space, but not into orbit. These two dogs were the first living higher organisms successfully recovered from a spaceflight. Both space dogs survived the flight, although one would die on a subsequent flight. The U.S. launched mice aboard spacecraft later that year; however, they failed to reach the altitude for true spaceflight.
On 3 November 1957, the second-ever orbiting spacecraft carried the first animal into orbit, the dog Laika, launched aboard the Soviet Sputnik 2 spacecraft (nicknamed 'Muttnik' in the West). Laika died during the flight, as was intended because the technology to return from orbit had not yet been developed. At least 10 other dogs were launched into orbit and numerous others on sub-orbital flights before the historic date of 12 April 1961, when Yuri Gagarin became the first human in space.
On 13 December 1958, a Jupiter IRBM, AM-13, was launched from Cape Canaveral, Florida, with a United States Navy-trained South American squirrel monkey named Gordo on board. The nose cone recovery parachute failed to operate and Gordo was lost. Telemetry data sent back during the flight showed that the monkey survived the 10 "g" of launch, 8 minutes of weightlessness and 40 "g" of reentry at 10,000 miles per hour (16,000 km/h). The nose cone sank 1,302 nautical miles (2,411 km) downrange from Cape Canaveral and was not recovered.
Monkeys Able and Baker became the first monkeys to survive spaceflight after their 1959 flight. On 28 May 1959, aboard Jupiter IRBM AM-18, were a 7-pound (3.18 kg) American-born rhesus monkey, Able, from Independence, Kansas, and an 11-ounce (310 g) squirrel monkey from Peru, Baker. The monkeys rode in the nose cone of the missile to an altitude of 360 miles (579 km) and a distance of 1,700 miles (2,735 km) down the Atlantic Missile Range from Cape Canaveral, Florida. They withstood forces 38 times the normal pull of gravity and were weightless for about 9 minutes. A top speed of 10,000 mph (16,000 km/h) was reached during their 16-minute flight. The monkeys survived the flight in good condition. Able died four days after the flight from a reaction to anesthesia, while undergoing surgery to remove an infected medical electrode. Baker was the center of media attention for the next several months as she was watched closely for any ill-effects from her space flight. She was even mated in an attempt to test her reproductive system. Baker lived until 29 November 1984, at the US Space and Rocket Center in Huntsville, Alabama.
On 2 July 1959, a launch of a Soviet R2 rocket, which reached 212 kilometers (132 mi), carried two space dogs and Marfusa, the first rabbit to go into space.
A 19 September 1959 launch, Jupiter AM-23, carried 2 frogs along with 12 mice but the rocket was destroyed during launch.
On 19 August 1960 Russia launched Sputnik 5 (also known as Korabl-Sputnik 2) which carried the dogs Belka and Strelka, along with a gray rabbit, 40 mice, 2 rats, and 15 flasks of fruit flies and plants. It was the first spacecraft to carry animals into orbit and return them alive. One of Strelka's pups, Pushinka, bred and born after her mission, was given as a present to Caroline Kennedy by Nikita Khrushchev in 1961, and many descendants are known to exist.
The United States sent 3 black mice Sally, Amy and Moe 1,000 km up and 8,000 km distance from Cape Canaveral on 13 October 1960 using an Atlas D 71D launch vehicle. The mice were retrieved from the nosecone near Ascension Island and were said to be in good condition.
On 31 January 1961, Ham the Chimp was launched in a Mercury capsule aboard a Redstone rocket. His mission was Mercury-Redstone 2. The chimp had been trained to pull levers to receive rewards of banana pellets and avoid electric shocks. His flight demonstrated the ability to perform tasks during spaceflight. A little over 3 months later the United States sent Alan Shepard into space. Enos the chimp became the first chimpanzee in orbit on 29 November 1961, in another Mercury capsule, an Atlas rocket, Mercury-Atlas 5.
On 9 March 1961 the Soviet Union launched the Korabl-Sputnik 4 that carried a dog named Chernushka, some mice, frogs and, for the first time into space, a guinea pig. All were successfully recovered.
On 18 October 1963, France launched Félicette the cat aboard Veronique AGI sounding rocket No. 47. The launch was directed by the French Centre d'Enseignement et de Recherches de Médecine Aéronautique (CERMA). Félicette was recovered alive after a 15-minute flight and a descent by parachute. Félicette had electrodes implanted into her brain, and the recorded neural impulses were transmitted back to Earth. A second cat was sent to space by CERMA on 24 October 1963. There was a delay in recovery of the capsule, and this cat was found dead when finally recovered.
The final French animal launches were of two monkeys in March 1967.
China launched mice and rats in 1964 and 1965, and two dogs in 1966.
During the Voskhod program, two Russian space dogs, Veterok (Ветерок, Little Wind) and Ugolyok (Уголёк, Blackie), were launched on 22 February 1966, on board Cosmos 110 and spent 22 days in orbit before landing on 16 March. This spaceflight of record-breaking duration was not surpassed by humans until Soyuz 11 in 1971 and still stands as the longest space flight by dogs.
On 11 April 1967, Argentina also launched the rat Belisario, atop a Yarará rocket, from Cordoba military range, which was recovered successfully. This flight was followed by a series of subsequent flights using rats. It is unclear if any Argentinean biological flights passed the 100 km limit of space.
The first two tortoises in space were launched on Zond 5 on 14 September 1968 by the Soviet Union. The Horsfield's tortoises were sent on a circumlunar voyage along with wine flies, meal worms, and other biological specimens. These were the first animals in deep space and the first inhabitants of earth to travel around the moon. The capsule overshot its terrestrial landing site but was successfully recovered at sea on 21 September. The animals survived but suffered some weight loss.
The United States launched the monkey Bonny, a macaque, in 1969 on the first multi-day primate mission; it was one of four U.S. monkey missions in the 1960s.
In total in the 1950s and 1960s, the Soviet Union launched missions with passenger slots for at least 57 dogs. The actual number of dogs in space is smaller, because some dogs flew more than once.
On 23 December 1969, as part of the 'Operación Navidad' (Operation Christmas), Argentina launched Juan (a cai monkey, native of Argentina's Misiones Province) using a Canopus II rocket. It ascended 82 kilometers and then was recovered successfully. Later, on 1 February 1970 the experience was repeated with a female monkey of the same species using a X-1 Panther rocket. It reached a higher altitude than its predecessor, but it was lost after the capsule's parachute failed.
Apollo 16 on 16 April 1972 carried nematodes, and Apollo 17, launched on 7 December 1972 carried five pocket mice, although one died on the circumlunar trip. Skylab 3 carried pocket mice and the first fish in space (a mummichog), and the first spiders in space (garden spiders named Arabella and Anita). Mummichog were also flown by the U.S. on the Apollo-Soyuz joint mission, launched 15 July 1975.
The Soviets flew several Bion program missions which consisted of satellites with biological cargoes. On these launches they flew tortoises, rats, and mummichog. On Soyuz 20, launched 17 November 1975, tortoises set the duration record for an animal in space when they spent 90.5 days in space. Salyut 5 on 22 June 1976, carried tortoises and a fish (a zebra danio).
The Soviet Union sent eight monkeys into space in the 1980s on Bion flights. In 1985, the U.S. sent two squirrel monkeys aboard Spacelab 3 on the Space Shuttle with 24 male albino rats and stick insect eggs. Bion flights also flew zebra danio, fruit flies, rats, stick insect eggs and the first newts in space.
Bion 7 (1985) had 10 newts (Pleurodeles waltl) on board. The newts had part of their front limbs amputated, to study the rate of regeneration in space, knowledge to understand human recovery from space injuries.
After an experiment was lost in the Space Shuttle Challenger disaster, chicken embryos (fertilized eggs) were sent into space in an experiment on STS-29 in 1989. The experiment was designed for a student contest.
Four monkeys flew aboard the last Bion flights of the Soviet Union as well as frogs and fruit flies. The Foton program flights carried dormant brine shrimp (Artemia franciscana), newts, fruit flies, and sand desert beetles (Trigonoscelis gigas).
Japan launched its first animals, a species of newt, into space on 18 March 1995 aboard the Space Flyer Unit.
During the 1990s the U.S. carried crickets, mice, rats, frogs, newts, fruit flies, snails, carp, medaka, oyster toadfish, sea urchins, swordtail fish, gypsy moth eggs, stick insect eggs, brine shrimp (Artemia salina), quail eggs, and jellyfish aboard Space Shuttles.
The last flight of Columbia in 2003 carried silkworms, garden orb spiders, carpenter bees, harvester ants, and Japanese killifish (medaka). Nematodes (C. elegans) from one experiment were found still alive in the debris after the Space Shuttle Columbia disaster.
Earlier shuttle missions included grade school, junior high and high school projects; some of these included ants, stick insect eggs and brine shrimp cysts. Other science missions included gypsy moth eggs.
On 12 July 2006, Bigelow Aerospace launched their Genesis I inflatable space module, containing many small items such as toys and simple experiments chosen by company employees that would be observed via camera. These items included insects, perhaps making it the first private flight to launch animals into space. Included were Madagascar hissing cockroaches and Mexican jumping beans — seeds containing live larvae of the moth Cydia deshaisiana. On 28 June 2007, Bigelow launched Genesis II, a near-twin to Genesis I. This spacecraft also carried the Madagascar hissing cockroaches and added South African flat rock scorpions (Hadogenes troglodytes) and seed-harvester ants (Pogonomyrmex californicus).
In September 2007, during the European Space Agency's FOTON-M3 mission, tardigrades, also known as water-bears, were able to survive 10 days of exposure to open-space with only their natural protection.
On the same mission, a number of cockroaches were carried inside a sealed container and at least one of the females conceived during the mission. After they were returned to earth, the one named Nadezhda became the first earth creature to produce young that had been conceived in space.
On 15 March 2009, during the countdown of the STS-119, a free-tailed bat was seen clinging to the fuel tank. NASA observers believed the bat would fly off once the shuttle started to launch, but it did not. Upon analyzing the images, a wildlife expert who provided support to the center said it likely had a broken left wing and some problem with its right shoulder or wrist. The animal most likely perished quickly during Discovery's climb into orbit.
On 3 February 2010, on the 31st anniversary of its revolution, Iran became the latest country to launch animals into space. The animals (a mouse, two turtles and some worms) were launched on top of the Kavoshgar 3 rocket and returned alive to Earth.
In May 2011, the last flight of Endeavour (STS-134) carried two golden orb spiders, named Gladys and Esmeralda, as well as a fruit fly colony as their food source in order to study the effects of microgravity on spiders' behavior. Tardigrades and other extremophiles were also sent into orbit.
On 28 January 2013, Iranian news agencies reported that Iran sent a monkey in a "Pishgam" rocket to a height of 72 miles (116 km) and retrieved a "shipment". Later Iran's space research website uploaded an 18-minute video. The video was uploaded later on YouTube.
On 19 July 2014, Russia announced that they launched their Foton-M4 satellite into low earth orbit (575 kilometers) with 1 male and 4 female geckos (possibly gold dust day geckos) as the payload. This was an effort to study the effects of microgravity on reproductive habits of reptiles. On 24 July 2014, it was announced that Russia had lost control of the Foton-M4 satellite, leaving only two months to restore contact before the geckos' food supply was exhausted. Control of the satellite was subsequently restored on 28 July 2014. On 1 September 2014 Russia confirmed the death of all five geckos, stating that their mummified bodies seem to indicate they froze to death. Russia is said to have appointed an emergency commission to investigate the animals' deaths.
On 14 April 2015, the SpaceX CRS-6 delivered 20 C57BL/6NTAC mice to live on the ISS for evaluating microgravity as the extreme opposite of a healthy active lifestyle. In the absence of gravity, astronauts are subject to a decrease in muscle, bone, and tendon mass. "Although, we’re not out to treat couch potatoes," states head Novartis Institute for Biomedical Research (NIBR) scientist on the project Dr. Sam Cadena, "we’re hoping that these experiments will help us to better understand muscle loss in populations where physical activity in any form is not an option; e.g., in the frail elderly or those subjected to bed rest or immobilization due to surgery or chronic disease." 
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